Abstract
Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants. Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.
Original language | English |
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Pages (from-to) | 35-45 |
Number of pages | 11 |
Journal | Brain and Language |
Volume | 194 |
DOIs | |
State | Published - Jul 2019 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Inc.
Funding
This work was supported by the National Institutes of Health (M.L.GT., NINDS R01 NS050915, NIDCD K24 DC015544; NIA U01 AG052943; M.H., R01DC016291-02; B.L.M., NIA P50 AG03006, NIA P50 AG023501, NIA P01 AG019724; N.D. NIDCD RO1 DC016345); State of California (M.L.GT., DHS04-35516); Alzheimer’s Disease Center of California (B.L.M., 03-75271 DHS/ADP/ARCC); John Douglas French Alzheimer’s Foundation (B.L.M.); Koret Family Foundation; The Bluefield Project to Cure Frontotemporal Dementia (B.L.M.); and McBean Family Foundation (B.L.M.). We thank our patients and healthy volunteers for participating in the research.
Funders | Funder number |
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Alzheimer’s Disease Center of California | 03-75271 DHS/ADP/ARCC |
John Douglas French Alzheimer’s Foundation | |
McBean Family Foundation | |
California State University | DHS04-35516 |
National Institutes of Health (NIH) | |
National Institute on Deafness and Other Communication Disorders | RO1 DC016345, K24 DC015544, P50 AG023501, R01DC016291-02, P01 AG019724, P50 AG03006, NIA U01 AG052943 |
National Institute on Deafness and Other Communication Disorders | |
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council | R01NS050915 |
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council | |
Koret Foundation |
Keywords
- Cortical thickness
- Length
- Phrase repetition
- Primary progressive aphasia
- Semantics
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Speech and Hearing
- Cognitive Neuroscience
- Language and Linguistics
- Linguistics and Language