Neuroendocrine influences and repercussions of the menopause

P. M. Wise, M. J. Smith, D. B. Dubal, M. E. Wilson, K. M. Krajnak, K. L. Rosewell

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


In summary, the evidence that both the ovary and the brain are key pacemakers in the menopause is compelling. Our appreciation that estrogens are important neurotrophic and neuroprotective factors has grown rapidly. Future studies will allow us to better understand the ensemble of factors that interact to maintain regular reproductive cyclicity and how this precise dynamic balance changes with age. Furthermore, understanding how estrogen exerts trophic and protective actions should lead to its use as an important therapeutic agent in the maintenance of normal neural function during aging and after injury.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalEndocrine Reviews
Issue number3
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Neuroendocrine influences and repercussions of the menopause'. Together they form a unique fingerprint.

Cite this