TY - JOUR
T1 - Neurofibrillary tangles in the cerebral cortex of sheep
AU - Nelson, Peter T.
AU - Greenberg, Sharon G.
AU - Saper, Clifford B.
PY - 1994/3/28
Y1 - 1994/3/28
N2 - Neurofibrillary degeneration, including neurofibrillary tangles (NFTs) and neuritic plaques, is an important pathological hallmark of Alzheimer's disease (AD). Unfortunately, no practical animal model of neurofibrillary degeneration has been described. We report here the presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble Alzheimer NFTs and neuritic plaques. NFT-like structures and clusters of degenerating neurites are stained by silver impregnation and thioflavin-S, and are immunoreactive with antibodies against tau microtubule-associated proteins. Viewed under the electron microscope, tau-immunoreactive tangles consist of paired helical filaments. Naturally occurring neurofibrillary structures in sheep cortex provide a model for studying the pathobiology of Alzheimer's disease.
AB - Neurofibrillary degeneration, including neurofibrillary tangles (NFTs) and neuritic plaques, is an important pathological hallmark of Alzheimer's disease (AD). Unfortunately, no practical animal model of neurofibrillary degeneration has been described. We report here the presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble Alzheimer NFTs and neuritic plaques. NFT-like structures and clusters of degenerating neurites are stained by silver impregnation and thioflavin-S, and are immunoreactive with antibodies against tau microtubule-associated proteins. Viewed under the electron microscope, tau-immunoreactive tangles consist of paired helical filaments. Naturally occurring neurofibrillary structures in sheep cortex provide a model for studying the pathobiology of Alzheimer's disease.
KW - Alzheimer's disease
KW - Amyloid
KW - Animal model
KW - Neurofibrillary tangle
KW - Paired helical filament
KW - Plaque
KW - Sheep
KW - Tau
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UR - http://www.scopus.com/inward/citedby.url?scp=0028231293&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90270-4
DO - 10.1016/0304-3940(94)90270-4
M3 - Article
C2 - 8041504
AN - SCOPUS:0028231293
SN - 0304-3940
VL - 170
SP - 187
EP - 190
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -