The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.
|Number of pages||4|
|State||Published - Aug 15 1994|
Bibliographical noteFunding Information:
This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.
- Choline acetyltransferase
- Cholinergic neuron
- Dementia of the Alzheimer type
- Lateral vestibular nucleus
- Neurofibrillary tangle
ASJC Scopus subject areas
- Neuroscience (all)