Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease

G. Ransmayr, H. Benesch, C. Nowakowski, G. Künig, H. Heinsen, P. Riederer, L. B. Hersh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalNeuroscience Letters
Volume177
Issue number1-2
DOIs
StatePublished - Aug 15 1994

Bibliographical note

Funding Information:
This project was supported by a grant from the Leopold Franzens University, lnnsbruck, 1992 and in part by the NIH Grant AG05893.

Keywords

  • Choline acetyltransferase
  • Cholinergic neuron
  • Dementia of the Alzheimer type
  • Immunohistochemistry
  • Lateral vestibular nucleus
  • Neurofibrillary tangle

ASJC Scopus subject areas

  • Neuroscience (all)

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