Neurohumoral variability in left ventricular dysfunction

Philip C. Kirlin, Claude Benedict, Brent J. Shelton, Gary Francis, John Nicklas, Chang Seng Liang, Spencer Kubo, David Johnstone, Jeffrey Probstfield, Salim Yusuf

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The immediate and longer term variability of selected vasoactive- and volume-regulating neurohormones were measured in patients entering a substudy of the Studies of Left Ventricular Dysfunction-a randomized clinical trial in patients with left ventricular ejection fraction <35%. The variability of these hormones has not been determined in a large cohort of patients. Immediate (short-term) variability was assessed by systematically comparing levels after 15 and 30 minutes of supine rest at the initial visit, and longer term variability was assessed by comparing 30-minute supine rest values at the initial visit with corresponding values taken at 30 minutes after 16 to 24 days of stable therapy. Initial values obtained at the first visit after 30-minute supine rest for all 209 patients were (mean ± SEM) 512 ± 21 pg/ml for plasma norepinephrine, 1.9 ± 0.2 ng/ml/hr for plasma renin activity, 3.0 ± 0.1 pg/ml for plasma arginine vasopressin, and 129 ± 5.3 pg/ml for plasma atrial natriuretic peptide. All variables were moderately increased relative to established normal values. There was a small but significant decrease from 15- to 30-minute supine posture in all neurohormones, except arginine vasopressin. In the presence of stable background therapy, no significant differences were found between measurements obtained after 30 minutes supine rest at the initial visit and 16 to 24 days later. Spearman correlation coefficients corresponding to immediate and longer term variability were high (range 0.55 to 0.79) (p < 0.0001). We conclude that plasma neurohormone levels are relatively constant over several weeks in patients with chronic left ventricular dysfunction who have received stable background therapy throughout this 3-week period. This suggests that major variations in plasma neurohormone levels may therefore be a possible marker of disease progression or may reflect treatment effects in this population.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalAmerican Journal of Cardiology
Issue number5-6
StatePublished - Feb 15 1995

Bibliographical note

Funding Information:
From Michigan State University, ,East lansing, Michigan; the Division of Cardiology, University of Texas Medical School, Houston, Texas; the Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, North Carolina; the Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota; the University of Michigan Hospital, Ann Arbor, Michi an; Strong Memorial Hospital; Cardiology Unit, University of Rot a ester, New York; the Cardiology Division, University of Minnesota, Minneapolis, Minnesota; Victoria General Hospital, Halifax, Nova Scotia, Canada; the Fred Hutchinson Cancer Research Center, Seattle, Washington; and the McMaster University Medical School, Hamilton, Ontario, Canada. Lhis study was supported by contracts from Studies of left Ventricu-sfunction, Clinical Trials Branch, National Heart, Lung, and Bloo % Institute, National Institutes of Health, Bethesda, Maryland. Manuscript received April 1.5, 1994; revised manuscript received and accepted October 12, 1994. Address for reprints: Salim Yusuf, MD, Cardiology Division, Room 614, McMaster Clinic, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L812X2.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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