TY - JOUR
T1 - Neuromolecular responses to social challenge
T2 - Common mechanisms across mouse, stickleback fish, and honey bee
AU - Rittschof, Clare C.
AU - Bukhari, Syed Abbas
AU - Sloofman, Laura G.
AU - Troy, Joseph M.
AU - Caetano-Anollés, Derek
AU - Cash-Ahmed, Amy
AU - Kent, Molly
AU - Lu, Xiaochen
AU - Sanogo, Yibayiri O.
AU - Weisner, Patricia A.
AU - Zhang, Huimin
AU - Bell, Alison M.
AU - Ma, Jian
AU - Sinha, Saurabh
AU - Robinson, Gene E.
AU - Stubbs, Lisa
N1 - Publisher Copyright:
© 2014, National Academy of Sciences. All rights reserved.
PY - 2014/12/16
Y1 - 2014/12/16
N2 - Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly conserved genes and networks that may be modified by lineage-specific mutations. However, the existence of deeply conserved mechanisms for social behaviors has not yet been demonstrated. We used a comparative genomics approach to determine whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range: house mouse (Mus musculus), stickleback fish (Gasterosteus aculeatus), and honey bee (Apis mellifera). Territory intrusion modulated similar brain functional processes in each species, including those associated with hormone-mediated signal transduction and neurodevelopment. Changes in chromosome organization and energy metabolism appear to be core, conserved processes involved in the response to territory intrusion. We also found that several homologous transcription factors that are typically associatedwith neural development were modulated across all three species, suggesting that shared neuronal effects may involve transcriptional cascades of evolutionarily conserved genes. Furthermore, immunohistochemical analyses of a subset of these transcription factors in mouse again implicated modulation of energy metabolism in the behavioral response. These results provide support for conserved genetic "toolkits" that are used in independent evolutions of the response to social challenge in diverse taxa.
AB - Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly conserved genes and networks that may be modified by lineage-specific mutations. However, the existence of deeply conserved mechanisms for social behaviors has not yet been demonstrated. We used a comparative genomics approach to determine whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range: house mouse (Mus musculus), stickleback fish (Gasterosteus aculeatus), and honey bee (Apis mellifera). Territory intrusion modulated similar brain functional processes in each species, including those associated with hormone-mediated signal transduction and neurodevelopment. Changes in chromosome organization and energy metabolism appear to be core, conserved processes involved in the response to territory intrusion. We also found that several homologous transcription factors that are typically associatedwith neural development were modulated across all three species, suggesting that shared neuronal effects may involve transcriptional cascades of evolutionarily conserved genes. Furthermore, immunohistochemical analyses of a subset of these transcription factors in mouse again implicated modulation of energy metabolism in the behavioral response. These results provide support for conserved genetic "toolkits" that are used in independent evolutions of the response to social challenge in diverse taxa.
KW - Aggression
KW - Brain metabolism
KW - Genetic hotspot
KW - Nf-κb signaling
UR - http://www.scopus.com/inward/record.url?scp=84918594653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918594653&partnerID=8YFLogxK
U2 - 10.1073/pnas.1420369111
DO - 10.1073/pnas.1420369111
M3 - Article
C2 - 25453090
AN - SCOPUS:84918594653
SN - 0027-8424
VL - 111
SP - 17929
EP - 17934
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 50
ER -