TY - JOUR
T1 - Neuronal accumulation of aluminum in dialysis encephalopathy
T2 - A laser microprobe study
AU - Galassi, G.
AU - Cappeli, G.
AU - Crisi, G.
AU - Botticelli, A. R.
AU - Lursvarghi, E.
AU - Winkelmann, M. D.
AU - Lovell, M. A.
AU - Ehmann, W. D.
AU - Markesbery, W. R.
PY - 1995
Y1 - 1995
N2 - Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.
AB - Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.
KW - Aluminum
KW - Dialysis encephalopathy
KW - Laser microprobe mass spectrometry
KW - Neurons
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M3 - Article
AN - SCOPUS:0028988008
SN - 0946-2104
VL - 12
SP - 68
EP - 73
JO - Trace Elements and Electrocytes
JF - Trace Elements and Electrocytes
IS - 2
ER -