Neuronal accumulation of aluminum in dialysis encephalopathy: A laser microprobe study

G. Galassi; G. Cappeli; G. Crisi; A. R. Botticelli; E. Lursvarghi; M. D. Winkelmann; M. A. Lovell; W. D. Ehmann; W. R. Markesbery

Neuronal accumulation of aluminum in dialysis encephalopathy: A laser microprobe study

G. Galassi, G. Cappeli, G. Crisi, A. R. Botticelli, E. Lursvarghi, M. D. Winkelmann, M. A. Lovell, W. D. Ehmann, W. R. Markesbery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.

Original language	English
Pages (from-to)	68-73
Number of pages	6
Journal	Trace Elements and Electrocytes
Volume	12
Issue number	2
State	Published - 1995

Keywords

Aluminum
Dialysis encephalopathy
Laser microprobe mass spectrometry
Neurons

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Inorganic Chemistry

Cite this

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title = "Neuronal accumulation of aluminum in dialysis encephalopathy: A laser microprobe study",

abstract = "Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.",

keywords = "Aluminum, Dialysis encephalopathy, Laser microprobe mass spectrometry, Neurons",

author = "G. Galassi and G. Cappeli and G. Crisi and Botticelli, {A. R.} and E. Lursvarghi and Winkelmann, {M. D.} and Lovell, {M. A.} and Ehmann, {W. D.} and Markesbery, {W. R.}",

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language = "English",

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pages = "68--73",

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T1 - Neuronal accumulation of aluminum in dialysis encephalopathy

T2 - A laser microprobe study

AU - Galassi, G.

AU - Cappeli, G.

AU - Crisi, G.

AU - Botticelli, A. R.

AU - Lursvarghi, E.

AU - Winkelmann, M. D.

AU - Lovell, M. A.

AU - Ehmann, W. D.

AU - Markesbery, W. R.

PY - 1995

Y1 - 1995

N2 - Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.

AB - Dialysis encephalopathy (DE), a fatal neurologic complication of patients with renal failure receiving chronic hemodialysis, is thought to be due to aluminum (Al) toxicity. We have used laser microprobe mass spectrometry to determine Al levels in hippocampal neurons of three autopsied DE patients and seven control subjects. Grand mean Al levels were significantly elevated in cytoplasm and nuclei of hippocampal neurons and adjacent neuropil of DE subjects compared with controls (p < 0.05). Our data indicate that hippocampal neurons in DE contain elevated Al and support the hypothesis that the neurologic manifestations of DE are related to Al toxicity.

KW - Aluminum

KW - Dialysis encephalopathy

KW - Laser microprobe mass spectrometry

KW - Neurons

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AN - SCOPUS:0028988008

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ER -

Neuronal accumulation of aluminum in dialysis encephalopathy: A laser microprobe study

Abstract

Keywords

ASJC Scopus subject areas

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