Neuronal deamination of endogenous and exogenous noradrenaline in the mesenteric artery of the spontaneously hypertensive rat

R. J. Head, L. A. Cassis, S. Barone, R. E. Stitzel, I. S. De La Lande

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6 Scopus citations

Abstract

The noradrenaline (NA) content of the mesenteric arteries from spontaneously‐hypertensive rats (SHR) are greater than those in arteries from normotensive Kyoto Wistar rats (WKY). The possibility that impaired neuronal monoamine oxidase (MAO) activity in mesenteric arteries from SHR rats was responsible for the differences in NA content was explored. The in‐vitro formation of dihydroxyphenylethylene glycol (DOPEG) by intact segments of mesenteric arteries was used as an index of neuronal MAO activity. There were no differences in the production of DOPEG from endogenous NA by arteries from normotensive and hypertensive rats. Moreover, the formation of DOPEG from exogenous NA was similar in arteries from SHR and WKY rats. The neuronal uptake of NA was indistinguishable between mesenteric arteries from SHR and WKY rats. The results argue against an impairment of neuronal MAO in contributing to the enhanced content of NA in the mesenteric artery of the SHR rat.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number6
DOIs
StatePublished - Jun 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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