TY - JOUR
T1 - Neuroprotective effects of the pyrrolopyrimidine U-104067F in 3- acetylpyridine-treated rats
AU - Sethy, Vimala H.
AU - Wu, Haiyan
AU - Oostveen, Jo A.
AU - Hall, Edward D.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/7
Y1 - 1996/7
N2 - The neuroprotective effects of U-104067F [(9-(2-morpholinyl)ethyl)2,4- di-1-pyrrolidinyl-9H-pyrimidino(4,5-b)indole monohydrochloride hydrate], a pyrrolopyrimidine antioxidant, were investigated in 3-acetylpyridine (3- AP)-treated Wistar rats. A significant (P < 0.01) reduction in cerebellar cGMP and ATP was observed at 96 h after treatment with 3-AP (500 μmol/kg ip). Oral administration of U-104067F significantly attenuated 3-AP-induced reductions in cGMP and ATP, and this effect was dose related. Consistent with the neurochemical effect, U-104067F prevented 3-AP-induced loss of motor coordination. 3-Acetylpyridine produced a significant (P < 0.01) loss of neurons in the inferior olivary nucleus. Treatment with U-104067F partially, but significantly (P < 0.01), prevented the loss of inferior olivary neurons. The physiological and neurochemical parameters were maintained within normal limits by U-104067F in 3-AP-treated rats despite only partial preservation of inferior olivary neurons.
AB - The neuroprotective effects of U-104067F [(9-(2-morpholinyl)ethyl)2,4- di-1-pyrrolidinyl-9H-pyrimidino(4,5-b)indole monohydrochloride hydrate], a pyrrolopyrimidine antioxidant, were investigated in 3-acetylpyridine (3- AP)-treated Wistar rats. A significant (P < 0.01) reduction in cerebellar cGMP and ATP was observed at 96 h after treatment with 3-AP (500 μmol/kg ip). Oral administration of U-104067F significantly attenuated 3-AP-induced reductions in cGMP and ATP, and this effect was dose related. Consistent with the neurochemical effect, U-104067F prevented 3-AP-induced loss of motor coordination. 3-Acetylpyridine produced a significant (P < 0.01) loss of neurons in the inferior olivary nucleus. Treatment with U-104067F partially, but significantly (P < 0.01), prevented the loss of inferior olivary neurons. The physiological and neurochemical parameters were maintained within normal limits by U-104067F in 3-AP-treated rats despite only partial preservation of inferior olivary neurons.
UR - http://www.scopus.com/inward/record.url?scp=0030199248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030199248&partnerID=8YFLogxK
U2 - 10.1006/exnr.1996.0117
DO - 10.1006/exnr.1996.0117
M3 - Article
C2 - 8682182
AN - SCOPUS:0030199248
SN - 0014-4886
VL - 140
SP - 79
EP - 83
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -