Neuroprotective effects of the pyrrolopyrimidine U-104067F in 3- acetylpyridine-treated rats

Vimala H. Sethy, Haiyan Wu, Jo A. Oostveen, Edward D. Hall

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11 Scopus citations


The neuroprotective effects of U-104067F [(9-(2-morpholinyl)ethyl)2,4- di-1-pyrrolidinyl-9H-pyrimidino(4,5-b)indole monohydrochloride hydrate], a pyrrolopyrimidine antioxidant, were investigated in 3-acetylpyridine (3- AP)-treated Wistar rats. A significant (P < 0.01) reduction in cerebellar cGMP and ATP was observed at 96 h after treatment with 3-AP (500 μmol/kg ip). Oral administration of U-104067F significantly attenuated 3-AP-induced reductions in cGMP and ATP, and this effect was dose related. Consistent with the neurochemical effect, U-104067F prevented 3-AP-induced loss of motor coordination. 3-Acetylpyridine produced a significant (P < 0.01) loss of neurons in the inferior olivary nucleus. Treatment with U-104067F partially, but significantly (P < 0.01), prevented the loss of inferior olivary neurons. The physiological and neurochemical parameters were maintained within normal limits by U-104067F in 3-AP-treated rats despite only partial preservation of inferior olivary neurons.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalExperimental Neurology
Issue number1
StatePublished - Jul 1996

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ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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