Neurotransmitter function presynaptic neurotransmission: Alterations in exocytotic/secretory machinery and glutamate signaling in kindling

S. R. Batten; S. W. Whiteheart; G. A. Gerhardt; J. T. Slevin

doi:10.1016/B978-0-12-809324-5.00151-6

Neurotransmitter function presynaptic neurotransmission: Alterations in exocytotic/secretory machinery and glutamate signaling in kindling

S. R. Batten, S. W. Whiteheart, G. A. Gerhardt, J. T. Slevin

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

We examined the synaptosomal proteins involved in neurotransmitter release and glutamatergic signaling to determine whether their alteration correlates with epileptogenesis. Hippocampal secretory machinery and glutamate signaling were analyzed in electrically kindled animals. Regardless of stimulation paradigm, there was a persistent, asymmetric accumulation of 7S SNARE Complexes (7SC) in ipsilateral hippocampi, which correlated with kindling progress and with dysregulation of glutamate signaling. SV2, tomosyn-1/STXBP5, and NSF showed alterations during kindling. Levetiracetam (LEV, a SV2A-binding, anti-convulsant) dampened 7SC accumulation and delayed kindling. The implications of our findings and their insights into epileptogenesis and epilepsy are discussed.

Original language	English
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Pages	892-897
Number of pages	6
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.00151-6
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.

Keywords

Epilepsy
Exocytosis
Kindling
Munc13
Munc18/Sec1
NSF
Neurotransmitter
SNAREs
SV2
Tomosyn-1/STXBP5

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-809324-5.00151-6

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abstract = "We examined the synaptosomal proteins involved in neurotransmitter release and glutamatergic signaling to determine whether their alteration correlates with epileptogenesis. Hippocampal secretory machinery and glutamate signaling were analyzed in electrically kindled animals. Regardless of stimulation paradigm, there was a persistent, asymmetric accumulation of 7S SNARE Complexes (7SC) in ipsilateral hippocampi, which correlated with kindling progress and with dysregulation of glutamate signaling. SV2, tomosyn-1/STXBP5, and NSF showed alterations during kindling. Levetiracetam (LEV, a SV2A-binding, anti-convulsant) dampened 7SC accumulation and delayed kindling. The implications of our findings and their insights into epileptogenesis and epilepsy are discussed.",

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Neurotransmitter function presynaptic neurotransmission: Alterations in exocytotic/secretory machinery and glutamate signaling in kindling. / Batten, S. R.; Whiteheart, S. W.; Gerhardt, G. A. et al.
The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. 2016. p. 892-897.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - Neurotransmitter function presynaptic neurotransmission

T2 - Alterations in exocytotic/secretory machinery and glutamate signaling in kindling

AU - Batten, S. R.

AU - Whiteheart, S. W.

AU - Gerhardt, G. A.

AU - Slevin, J. T.

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N2 - We examined the synaptosomal proteins involved in neurotransmitter release and glutamatergic signaling to determine whether their alteration correlates with epileptogenesis. Hippocampal secretory machinery and glutamate signaling were analyzed in electrically kindled animals. Regardless of stimulation paradigm, there was a persistent, asymmetric accumulation of 7S SNARE Complexes (7SC) in ipsilateral hippocampi, which correlated with kindling progress and with dysregulation of glutamate signaling. SV2, tomosyn-1/STXBP5, and NSF showed alterations during kindling. Levetiracetam (LEV, a SV2A-binding, anti-convulsant) dampened 7SC accumulation and delayed kindling. The implications of our findings and their insights into epileptogenesis and epilepsy are discussed.

AB - We examined the synaptosomal proteins involved in neurotransmitter release and glutamatergic signaling to determine whether their alteration correlates with epileptogenesis. Hippocampal secretory machinery and glutamate signaling were analyzed in electrically kindled animals. Regardless of stimulation paradigm, there was a persistent, asymmetric accumulation of 7S SNARE Complexes (7SC) in ipsilateral hippocampi, which correlated with kindling progress and with dysregulation of glutamate signaling. SV2, tomosyn-1/STXBP5, and NSF showed alterations during kindling. Levetiracetam (LEV, a SV2A-binding, anti-convulsant) dampened 7SC accumulation and delayed kindling. The implications of our findings and their insights into epileptogenesis and epilepsy are discussed.

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KW - Exocytosis

KW - Kindling

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KW - Munc18/Sec1

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KW - SNAREs

KW - SV2

KW - Tomosyn-1/STXBP5

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Neurotransmitter function presynaptic neurotransmission: Alterations in exocytotic/secretory machinery and glutamate signaling in kindling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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