Neurturin effects on nigrostriatal dopamine release and content: Comparison with GDNF

Wayne A. Cass, Laura E. Peters

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Neurturin (NTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family; and, while GDNF has been shown to increase dopamine (DA) release in normal animals, the ability of NTN to alter DA release has not been previously reported. The purpose of the present study was to determine if NTN could alter striatal DA release, and to compare the effects of NTN to GDNF. Male Fischer-344 rats were given a single injection of vehicle or 5 lg NTN or GDNF into the right substantia nigra. Three weeks later microdialysis experiments were conducted to assess striatal DA release. Basal extracellular levels of striatal DA were not affected by either NTN or GDNF. However, both NTN and GDNF led to increases in amphetamine-evoked overflow of DA from the ipsilateral striatum, and there was a trend for potassium-evoked overflow to be augmented. Postmortem tissue levels of DA were decreased by approximately 20% in the striatum, andincreased by approximately 100% in the substantia nigra, on the ipsilateral side of the brain compared to the contralateral side following both NTN and GDNF injection. Thus, NTN, like GDNF, can augment striatal DA release, and the magnitude of the NTN effects are similar to those of GDNF.

Original languageEnglish
Pages (from-to)727-734
Number of pages8
JournalNeurochemical Research
Volume35
Issue number5
DOIs
StatePublished - May 2010

Bibliographical note

Funding Information:
Acknowledgments This study was supported in part by United States Public Health Service Grant AG17963.

Keywords

  • Dopamine
  • GDNF
  • Microdialysis
  • Neurturin
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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