TY - JOUR
T1 - Neutrophils in triple-negative breast cancer
T2 - an underestimated player with increasingly recognized importance
AU - Zheng, Chanjuan
AU - Xu, Xi
AU - Wu, Muyao
AU - Xue, Lian
AU - Zhu, Jianyu
AU - Xia, Hongzhuo
AU - Ding, Siyu
AU - Fu, Shujun
AU - Wang, Xinyu
AU - Wang, Yian
AU - He, Guangchun
AU - Liu, Xia
AU - Deng, Xiyun
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with limited therapeutic options readily available. Immunotherapy such as immune checkpoint inhibition has been investigated in TNBC but still encounters low overall response. Neutrophils, the most abundant leukocytes in the body, are increasingly recognized as an active cancer-modulating entity. In the bloodstream, neutrophils escort circulating tumor cells to promote their survival and stimulate their proliferation and metastasis. In the tumor microenvironment, neutrophils modulate the immune milieu through polarization between the anti-tumor and the pro-tumor phenotypes. Through a comprehensive review of recently published literature, it is evident that neutrophils are an important player in TNBC immunobiology and can be used as an important prognostic marker of TNBC. Particularly, in their pro-tumor form, neutrophils facilitate TNBC metastasis through formation of neutrophil extracellular traps and the pre-metastatic niche. These findings will help advance the potential utilization of neutrophils as a therapeutic target in TNBC.
AB - Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with limited therapeutic options readily available. Immunotherapy such as immune checkpoint inhibition has been investigated in TNBC but still encounters low overall response. Neutrophils, the most abundant leukocytes in the body, are increasingly recognized as an active cancer-modulating entity. In the bloodstream, neutrophils escort circulating tumor cells to promote their survival and stimulate their proliferation and metastasis. In the tumor microenvironment, neutrophils modulate the immune milieu through polarization between the anti-tumor and the pro-tumor phenotypes. Through a comprehensive review of recently published literature, it is evident that neutrophils are an important player in TNBC immunobiology and can be used as an important prognostic marker of TNBC. Particularly, in their pro-tumor form, neutrophils facilitate TNBC metastasis through formation of neutrophil extracellular traps and the pre-metastatic niche. These findings will help advance the potential utilization of neutrophils as a therapeutic target in TNBC.
KW - Immunotherapy
KW - Metastasis
KW - Neutrophil
KW - Triple-negative breast cancer
KW - Tumor microenvironment
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U2 - 10.1186/s13058-023-01676-7
DO - 10.1186/s13058-023-01676-7
M3 - Review article
C2 - 37496019
AN - SCOPUS:85165632405
SN - 1465-5411
VL - 25
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 88
ER -