TY - JOUR
T1 - New and investigational treatment options for ischemic stroke
AU - Ryan, Melody
AU - Rhoney, Denise H.
AU - Luer, Mark S.
AU - Hatton, Jimmi
PY - 1997
Y1 - 1997
N2 - We conducted a MEDLINE search of new treatment strategies and experimental agents for treating acute ischemic stroke published from 1989- 1996. Clinical trials involving thrombolytics, glutamine release inhibition, N-methyl-D-aspartate receptor antagonism, opioid antagonism, calcium channel blockade, free radical scavenging, membrane stabilization, intercellular adhesion molecule-1 antagonism, ganglioside administration, and growth factor administration were included. Basic research articles were selected based on progress of the therapeutic class toward clinical trials. Approval of tissue plasminogen activator indicates progress in new treatments for acute ischemic stroke. Experimental therapies with potential may become available soon. Recognizing signs and symptoms of stroke is crucial to ensure prompt administration of these agents. The time to diagnosis determines the therapeutic approach for acute ischemic stroke.
AB - We conducted a MEDLINE search of new treatment strategies and experimental agents for treating acute ischemic stroke published from 1989- 1996. Clinical trials involving thrombolytics, glutamine release inhibition, N-methyl-D-aspartate receptor antagonism, opioid antagonism, calcium channel blockade, free radical scavenging, membrane stabilization, intercellular adhesion molecule-1 antagonism, ganglioside administration, and growth factor administration were included. Basic research articles were selected based on progress of the therapeutic class toward clinical trials. Approval of tissue plasminogen activator indicates progress in new treatments for acute ischemic stroke. Experimental therapies with potential may become available soon. Recognizing signs and symptoms of stroke is crucial to ensure prompt administration of these agents. The time to diagnosis determines the therapeutic approach for acute ischemic stroke.
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U2 - 10.1002/j.1875-9114.1997.tb03785.x
DO - 10.1002/j.1875-9114.1997.tb03785.x
M3 - Review article
C2 - 9324184
AN - SCOPUS:0030778895
SN - 0277-0008
VL - 17
SP - 959
EP - 969
JO - Pharmacotherapy
JF - Pharmacotherapy
IS - 5 I
ER -