TY - JOUR
T1 - New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop
AU - Telpoukhovskaia, Maria A.
AU - Murdy, Thomas J.
AU - Marola, Olivia J.
AU - Charland, Kevin
AU - MacLean, Michael
AU - Luquez, Tain
AU - Lish, Alexandra M.
AU - Neuner, Sarah
AU - Dunn, Amy
AU - Onos, Kristen D.
AU - Wiley, Jesse
AU - Archer, Derek
AU - Huentelman, Matthew J.
AU - Arnold, Matthias
AU - Menon, Vilas
AU - Goate, Alison
AU - Van Eldik, Linda J.
AU - Territo, Paul R.
AU - Howell, Gareth R.
AU - Carter, Gregory W.
AU - O'Connell, Kristen M.S.
AU - Kaczorowski, Catherine C.
N1 - Publisher Copyright:
© 2024 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic. RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.
AB - INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic. RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.
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U2 - 10.1002/trc2.12458
DO - 10.1002/trc2.12458
M3 - Review article
AN - SCOPUS:85187174689
VL - 10
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
M1 - e12458
ER -
