New insights into the role of nuclear factor-κB in cell growth regulation

F. Chen, V. Castranova, X. Shi

Research output: Contribution to journalReview articlepeer-review

446 Scopus citations

Abstract

The nuclear factor (NF)-κB family of eukaryotic transcription factors plays an important role in the regulation of immune response, embryo and cell lineage development, cell apoptosis, cell-cycle progression, inflammation, and oncogenesis. A wide range of stimuli, including cytokines, mitogens, environmental particles, toxic metals, and viral or bacterial products, activate NF-κB, mostly through IκB kinase (IKK)-dependent phosphorylation and subsequent degradation of its inhibitor, the IκB family of proteins. Activated NF-κB translocates into the nucleus where it modulates the expression of a variety of genes, including those encoding cytokines, growth factors, acute phase response proteins, cell adhesion molecules, other transcription factors, and several cell apoptosis regulators. During the past few years, tremendous progress has been achieved in our understanding on how intracellular signaling pathways are transmitted in either a linear or a network manner leading to the activation of NF-κB and subsequent cell growth control. However, a detailed molecular mechanism of NF-κB regulating cell growth has yet to be determined. Elucidation of the relationships between NF-κB activation and cell growth will be important in developing new strategies for the treatment of various human diseases, such as chronic autoimmune disorder and cancer.

Original languageEnglish
Pages (from-to)387-397
Number of pages11
JournalAmerican Journal of Pathology
Volume159
Issue number2
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
Supported by a Career Development Award in Genetics under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of Teachers of Preventive Medicine (to F. C.).

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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