New perspectives in arsenic-induced cell signal transduction

Yong Qian, Vince Castranova, Xianglin Shi

Research output: Contribution to journalShort surveypeer-review

95 Scopus citations

Abstract

Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-κB activation, cell cycle arrest, and apoptosis.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume96
Issue number2-3
DOIs
StatePublished - Aug 1 2003

Keywords

  • Apoptosis
  • Arsenic
  • Cell cycle
  • MAPK
  • Metal
  • NF-κB
  • Reactive oxygen species
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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