TY - JOUR
T1 - New perspectives in arsenic-induced cell signal transduction
AU - Qian, Yong
AU - Castranova, Vince
AU - Shi, Xianglin
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-κB activation, cell cycle arrest, and apoptosis.
AB - Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-κB activation, cell cycle arrest, and apoptosis.
KW - Apoptosis
KW - Arsenic
KW - Cell cycle
KW - MAPK
KW - Metal
KW - NF-κB
KW - Reactive oxygen species
KW - Tyrosine phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=12444271301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12444271301&partnerID=8YFLogxK
U2 - 10.1016/S0162-0134(03)00235-6
DO - 10.1016/S0162-0134(03)00235-6
M3 - Short survey
C2 - 12888263
AN - SCOPUS:12444271301
SN - 0162-0134
VL - 96
SP - 271
EP - 278
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 2-3
ER -