During histogenesis of the vertebrate central nervous system (CNS), neuronal progenitors must interact with germinal zone (GZ) niches, differentiate, and morphologically mature, and neurons must migrate to their final positions. The extrinsic cues that control neurogenesis, specify neurons, and guide their movement are relatively well understood. However, less is known about how neurons spatiotemporally modify cell-cell interactions and cell polarization to navigate through complex, distinct cellular environments during neuronal circuit formation. Here we examine the parallels between the mechanisms controlling epithelial morphogenesis and the cell adhesion events by which neural cells organize GZ niches and direct neuronal migration. We focus on the emerging relationship between neuronal adhesive interactions and conserved cell-polarity signaling cascades.
|Number of pages||11|
|Journal||Trends in Neurosciences|
|State||Published - Mar 2013|
Bibliographical noteFunding Information:
We thank Niraj Trivedi and Shalini Singh for critical reading of the manuscript. Sharon Naron provided expert editorial support. The Solecki Laboratory is funded by the American Lebanese Syrian Associated Charities (ALSAC), by grant #1-FY12-455 from the March of Dimes, and by grant 1R01NS066936 from the National Institute of Neurological Disorders and Stroke (NINDS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NINDS or the National Institutes of Health. J.K.F. is the recipient of Canadian Institutes of Health Research and Alberta Innovates Health Solutions postdoctoral fellowships.
- Adherens junction
- Cell adhesion
- Cell polarity
- PAR complex
ASJC Scopus subject areas
- Neuroscience (all)