New trends in the use of aminoglycosides

Marina Y. Fosso; Yijia Li; Sylvie Garneau-Tsodikova

doi:10.1039/c4md00163j

New trends in the use of aminoglycosides

Marina Y. Fosso, Yijia Li, Sylvie Garneau-Tsodikova

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Despite their inherent toxicity and the acquired bacterial resistance that continuously threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable components of the antibiotic armamentarium. Recent literature shows that the AGs' role has been further expanded as multi-tasking players in different areas of study. This review aims at presenting some of the new trends observed in the use of AGs in the past decade, along with the current understanding of their mechanisms of action in various bacterial and eukaryotic cellular processes. This journal is

Original language	English
Pages (from-to)	1075-1091
Number of pages	17
Journal	MedChemComm
Volume	5
Issue number	8
DOIs	https://doi.org/10.1039/c4md00163j
State	Published - Aug 2014

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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abstract = "Despite their inherent toxicity and the acquired bacterial resistance that continuously threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable components of the antibiotic armamentarium. Recent literature shows that the AGs' role has been further expanded as multi-tasking players in different areas of study. This review aims at presenting some of the new trends observed in the use of AGs in the past decade, along with the current understanding of their mechanisms of action in various bacterial and eukaryotic cellular processes. This journal is",

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AU - Li, Yijia

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AB - Despite their inherent toxicity and the acquired bacterial resistance that continuously threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable components of the antibiotic armamentarium. Recent literature shows that the AGs' role has been further expanded as multi-tasking players in different areas of study. This review aims at presenting some of the new trends observed in the use of AGs in the past decade, along with the current understanding of their mechanisms of action in various bacterial and eukaryotic cellular processes. This journal is

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New trends in the use of aminoglycosides

Abstract

ASJC Scopus subject areas

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