NF-κB prevents cells from undergoing Cr(VI)-induced apoptosis

Suwei Wang, Fei Chen, Zhuo Zhang, Bing Hua Jiang, Luo Jia, Xianglin Shi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The transcription factor NF-κB has been reported to prevent cells from undergoing apoptosis as well as promote cell apoptosis. To investigate the role of NF-κB in Cr(VI)-induced apoptosis, two cell lines were developed from human bronchial epithelial BEAS-2B cells: IKK cells, which were stably transfected with IκBα expression vector, that have normal NF-κB activity, and KM cells, which were stably transfected with mutated IκBα, kinase expression vector, that exhibit very little NF-κB activity. With Cr(VI) stimulation, KM cells, but not IKK cells, exhibited substantial cell death. Cell morphological and TUNEL analyses indicated that the KM cells showed apoptotic features. These results suggest that NF-κB activation is required to prevent the cells from undergoing Cr(VI)-induced apoptosis.

Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - Jan 2004


  • Cr(VI)
  • IKK
  • N-terminal phosphorylation
  • NF-κB activation

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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