Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats

Dustin J. Stairs, Nichole M. Neugebauer, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


There appears to be a relatively narrow range of contingencies in which intravenous (i.v) infusions of nicotine will maintain responding in rats. The schedule of reinforcement typically used when investigating i.v. nicotine self-administration is a simple fixed-ratio (FR) schedule. This study determined if responding in rats could be established using a multiple schedule of either i.v. cocaine or nicotine and sucrose reinforcement. Following training of individual components with each reinforcer, rats were placed on an FR15 60-s timeout multiple schedule of cocaine (0.3mg/kg/infusion) and sucrose (45mg pellets) reinforcement or an FR5 60-s timeout multiple schedule of nicotine (0.03mg/kg/infusion) and sucrose (45mg pellets) reinforcement. Both cocaine and nicotine maintained significant levels of responding under the multiple schedule. Pretreatment with the dopamine D1 antagonist SCH 23390 increased cocaine-maintained responding, but not sucrose responding. Acute pretreatment with the nicotinic antagonist mecamylamine or SCH 23390 specifically decreased nicotine self-administration. Extinction of the individual nicotine and sucrose components resulted in decreases in responding in each component under extinction. These results indicate that i.v. nicotine maintains responding under a multiple schedule. This procedure may be useful when studying the specificity of drug pretreatments on nicotine self-administration.

Original languageEnglish
Pages (from-to)182-193
Number of pages12
JournalBehavioural Pharmacology
Issue number3
StatePublished - May 2010


  • Cocaine
  • Mecamylamine
  • Multiple schedule
  • Nicotine
  • Rats
  • SCH 23390
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


Dive into the research topics of 'Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats'. Together they form a unique fingerprint.

Cite this