Nicotine enhances dopamine clearance in rat nucleus accumbens

Charles Ksir; Glenn Mellor; Carl Hart; Greg A. Gerhardt

doi:10.1016/0278-5846(94)00111-T

Nicotine enhances dopamine clearance in rat nucleus accumbens

Charles Ksir, Glenn Mellor, Carl Hart, Greg A. Gerhardt

Research output: Contribution to journal › Article › peer-review

Abstract

1. 1. Adult male rats were urethane-anesthetized and prepared for acute in-vivo voltammetric recording in the nucleus accumbens. 2. 2. Small amounts of 200 μM dopamine were pressure ejected near the tip of the recording electrode at 5-min intervals, while the peak concentration and time course of dopamine clearance were measured voltammetrically. 3. 3. After stable peak amplitudes were established, nicotine (0.4 mg/kg) was injected systemically. 4. 4. Dopamine peak amplitudes decreased following nicotine injection, presumably due to enhanced dopamine reuptake.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0278-5846(94)00111-T
State	Published - Jan 1995

Keywords

dopamine transporter
in-vivo voltammetry

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/0278-5846(94)00111-T

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title = "Nicotine enhances dopamine clearance in rat nucleus accumbens",

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KW - in-vivo voltammetry

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Nicotine enhances dopamine clearance in rat nucleus accumbens

Abstract

Keywords

ASJC Scopus subject areas

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