Nicotine enhances dopamine clearance in rat nucleus accumbens

Charles Ksir, Glenn Mellor, Carl Hart, Greg A. Gerhardt

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


1. 1. Adult male rats were urethane-anesthetized and prepared for acute in-vivo voltammetric recording in the nucleus accumbens. 2. 2. Small amounts of 200 μM dopamine were pressure ejected near the tip of the recording electrode at 5-min intervals, while the peak concentration and time course of dopamine clearance were measured voltammetrically. 3. 3. After stable peak amplitudes were established, nicotine (0.4 mg/kg) was injected systemically. 4. 4. Dopamine peak amplitudes decreased following nicotine injection, presumably due to enhanced dopamine reuptake.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
StatePublished - Jan 1995


  • dopamine transporter
  • in-vivo voltammetry

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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