TY - JOUR
T1 - Nicotine enhances dopamine clearance in rat nucleus accumbens
AU - Ksir, Charles
AU - Mellor, Glenn
AU - Hart, Carl
AU - Gerhardt, Greg A.
PY - 1995/1
Y1 - 1995/1
N2 - 1. 1. Adult male rats were urethane-anesthetized and prepared for acute in-vivo voltammetric recording in the nucleus accumbens. 2. 2. Small amounts of 200 μM dopamine were pressure ejected near the tip of the recording electrode at 5-min intervals, while the peak concentration and time course of dopamine clearance were measured voltammetrically. 3. 3. After stable peak amplitudes were established, nicotine (0.4 mg/kg) was injected systemically. 4. 4. Dopamine peak amplitudes decreased following nicotine injection, presumably due to enhanced dopamine reuptake.
AB - 1. 1. Adult male rats were urethane-anesthetized and prepared for acute in-vivo voltammetric recording in the nucleus accumbens. 2. 2. Small amounts of 200 μM dopamine were pressure ejected near the tip of the recording electrode at 5-min intervals, while the peak concentration and time course of dopamine clearance were measured voltammetrically. 3. 3. After stable peak amplitudes were established, nicotine (0.4 mg/kg) was injected systemically. 4. 4. Dopamine peak amplitudes decreased following nicotine injection, presumably due to enhanced dopamine reuptake.
KW - dopamine transporter
KW - in-vivo voltammetry
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U2 - 10.1016/0278-5846(94)00111-T
DO - 10.1016/0278-5846(94)00111-T
M3 - Article
C2 - 7708927
AN - SCOPUS:0028836423
SN - 0278-5846
VL - 19
SP - 151
EP - 156
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 1
ER -