Nimesulide inhibits IFN-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms

Mei Liang, Hui Yang, Jian Fu

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

It is now well established that increased programmed death-1-ligand 1 (PD-L1) surface expression in cancer cells and the resultant T cell suppression contribute to cancer cell immune evasion. Blockade of PD-L1 function has been shown to stimulate anti-cancer immunity. Therefore, compounds that can down-regulate PD-L1 surface expression in cancer cells may serve as novel immune modulators to promote cancer cell-reactive immune responses. In the present study, we examined the effects of nimesulide, a selective COX-2 inhibitor, on PD-L1 surface expression in breast cancer cells by flow cytometry. We demonstrated that nimesulide was able to inhibit IFN-γ-induced PD-L1 surface expression in breast cancer cells. However, our data indicate that the inhibitory effects of nimesulide appear to be independent of COX-2/PGE2 signaling. Since nimesulide also exhibits anti-tumor activities by inducing cancer cell apoptosis and inhibiting cancer cell proliferation, our findings suggest that nimesulide may represent a new class of chemotherapeutic agents that possess dual functions to inhibit cancer cell growth and promote cancer cell immune responses.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalCancer Letters
Volume276
Issue number1
DOIs
StatePublished - Apr 8 2009

Keywords

  • B7-H1
  • Breast cancer
  • Interferon
  • Nimesulide
  • PD-L1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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