Nitrated Proteins in the Progression of Alzheimer’s Disease: A Proteomics Comparison of Mild Cognitive Impairment and Alzheimer’s Disease Brain

Rukhsana Sultana, Renã A. Sowell, D. Allan Butterfield

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Oxidative stress and nitrosative stress have been reported to play important roles in the pathogenesis of a number of diseases including neurodegenerative diseases, cancer, ischemia, etc. Reactive nitrogen species are highly reactive and unstable. One of the best ways to quantify the amount of nitrosative stress is to measure the levels of 3-nitrotyrosine level. In addition, by using proteomics selective targets of protein nitration can be identified. In this chapter we discuss the roles of proteomics-identified nitrated brain proteins to the pathology of both mild cognitive impairment and Alzheimer’s disease. The identity of these nitrated proteins improves understanding of the role of nitrosative stress in the pathogenesis and progression of disease from MCI to AD. Such studies could also help in early detection and may provide therapeutic targets for early treatment that may slow disease progression.

Original languageEnglish
Title of host publicationContemporary Clinical Neuroscience
Pages137-157
Number of pages21
DOIs
StatePublished - 2009

Publication series

NameContemporary Clinical Neuroscience
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341

Bibliographical note

Publisher Copyright:
© 2009, Humana Press, a part of Springer Science+Business Media, LLC.

Keywords

  • 3-nitrotyrosine
  • Alzheimer’s disease
  • Mild cognitive impairment
  • Nitrosative stress
  • Proteomics

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Behavioral Neuroscience

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