Nitric oxide, caveolae, and vascular pathology

Xiang An Li, William Everson, Eric J. Smart

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Endothelial nitric oxide synthase (eNOS) is an enzyme that plays a critical role in normal cardiovascular function. Caveolae are structures within the surface membrane of cells in which many signaling and second messenger pathways, including nitric oxide, are regulated. Many interventions in cardiovascular disease act, in part, either by changing factors that directly influence eNOS, or by changing a complex set of proteins that act indirectly on caveolae, to alter eNOS activity. In this review, we will focus on the regulation of eNOS activity by circulating factors which are altered in cardiovascular disease and the effects of pharmacological interventions that act partially through effects on eNOS.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalCardiovascular Toxicology
Volume6
Issue number1
DOIs
StatePublished - Mar 2006

Keywords

  • AMP kinase
  • CD36
  • Diabetes
  • Endothelial nitric oxide synthase
  • Scavenger receptor BI
  • eNOS

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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