Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity

Vittorio Calabrese; Cesare Mancuso; Menotti Calvani; Enrico Rizzarelli; D. Allan Butterfield; Anna Maria Giuffrida Stella

doi:10.1038/nrn2214

Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity

Vittorio Calabrese, Cesare Mancuso, Menotti Calvani, Enrico Rizzarelli, D. Allan Butterfield, Anna Maria Giuffrida Stella

Research output: Contribution to journal › Review article › peer-review

1267 Citations (SciVal)

Abstract

At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.

Original language	English
Pages (from-to)	766-775
Number of pages	10
Journal	Nature Reviews Neuroscience
Volume	8
Issue number	10
DOIs	https://doi.org/10.1038/nrn2214
State	Published - Oct 2007

Bibliographical note

Funding Information:
This work was supported by grants from Ministero dell’Università e della Ricerca Cofin 2000, Progetti di Ricerca di Interesse Nazionale 2005, Fondo per gli Investimenti della Ricerca di Base RBNE01ZK8F and by National Institutes of Health grant AG-10836; AG-05119.

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nrn2214

Cite this

@article{9966674c483142689a0cee44bfd003b9,

title = "Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity",

abstract = "At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.",

author = "Vittorio Calabrese and Cesare Mancuso and Menotti Calvani and Enrico Rizzarelli and Butterfield, {D. Allan} and {Giuffrida Stella}, {Anna Maria}",

note = "Funding Information: This work was supported by grants from Ministero dell{\textquoteright}Universit{\`a} e della Ricerca Cofin 2000, Progetti di Ricerca di Interesse Nazionale 2005, Fondo per gli Investimenti della Ricerca di Base RBNE01ZK8F and by National Institutes of Health grant AG-10836; AG-05119.",

year = "2007",

month = oct,

doi = "10.1038/nrn2214",

language = "English",

volume = "8",

pages = "766--775",

number = "10",

}

TY - JOUR

T1 - Nitric oxide in the central nervous system

T2 - Neuroprotection versus neurotoxicity

AU - Calabrese, Vittorio

AU - Mancuso, Cesare

AU - Calvani, Menotti

AU - Rizzarelli, Enrico

AU - Butterfield, D. Allan

AU - Giuffrida Stella, Anna Maria

N1 - Funding Information: This work was supported by grants from Ministero dell’Università e della Ricerca Cofin 2000, Progetti di Ricerca di Interesse Nazionale 2005, Fondo per gli Investimenti della Ricerca di Base RBNE01ZK8F and by National Institutes of Health grant AG-10836; AG-05119.

PY - 2007/10

Y1 - 2007/10

N2 - At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.

AB - At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.

UR - http://www.scopus.com/inward/record.url?scp=34648836983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34648836983&partnerID=8YFLogxK

U2 - 10.1038/nrn2214

DO - 10.1038/nrn2214

M3 - Review article

C2 - 17882254

AN - SCOPUS:34648836983

SN - 1471-003X

VL - 8

SP - 766

EP - 775

JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

IS - 10

ER -

Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this