TY - JOUR
T1 - No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer
AU - Phillips, Lynette S.
AU - Thompson, Cheryl L.
AU - Merkulova, Alona
AU - Plummer, Sarah J.
AU - Tucker, Thomas C.
AU - Casey, Graham
AU - Li, Li
PY - 2009
Y1 - 2009
N2 - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
AB - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
KW - Candidate gene
KW - Colon cancer
KW - Genetic polymorphisms
KW - Phosphatase and tensin homolog
KW - Single nucleotide polymorphism association
UR - http://www.scopus.com/inward/record.url?scp=70350458592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350458592&partnerID=8YFLogxK
U2 - 10.3748/wjg.15.3771
DO - 10.3748/wjg.15.3771
M3 - Article
C2 - 19673018
AN - SCOPUS:70350458592
SN - 1007-9327
VL - 15
SP - 3771
EP - 3775
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 30
ER -
