Abstract
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
| Original language | English |
|---|---|
| Pages (from-to) | 3771-3775 |
| Number of pages | 5 |
| Journal | World Journal of Gastroenterology |
| Volume | 15 |
| Issue number | 30 |
| DOIs | |
| State | Published - 2009 |
Funding
| Funders | Funder number |
|---|---|
| National Childhood Cancer Registry – National Cancer Institute | K22CA120545 |
| National Childhood Cancer Registry – National Cancer Institute |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Candidate gene
- Colon cancer
- Genetic polymorphisms
- Phosphatase and tensin homolog
- Single nucleotide polymorphism association
ASJC Scopus subject areas
- Gastroenterology
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