No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample

C. Vaquero Lorenzo, E. Baca-Garcia, M. Diaz Hernandez, C. Botillo Martin, M. M. Perez-Rodriguez, M. D. Saiz-Gonzalez, P. Fernández, F. J. Quintero Gutierrez, J. Saiz-Ruiz, J. Fernandez Piqueras, J. L. Gonzalez De Rivera, J. De Leon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This study aims to further evaluate the controversial association between the Ser9Gly polymorphism in codon 9 of the D3 dopamine receptor gene (DRD3) and schizophrenia in psychiatric inpatients acutely hospitalized in two general hospitals in Madrid, Spain. The Ser9Gly polymorphism of the DRD3 was examined in 178 schizophrenic patients, 286 patients with other psychiatric diagnoses, and 132 controls recruited. Genotype frequencies were in Hardy-Weinberg equilibrium. No association was found between schizophrenia and the Ser9Gly polymorphism of the D3 dopamine receptor gene.

Original languageEnglish
Pages (from-to)344-346
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number3
DOIs
StatePublished - Apr 5 2007

Keywords

  • Association study
  • DRD3 gene
  • Genetics
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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