No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Rahul Sachdeva; Ali Hosseinzadeh; Aaron Rizzardo; Andrea Maharaj; Michael Berger; Andrei Krassioukov

doi:10.1002/acn3.51734

No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Rahul Sachdeva, Ali Hosseinzadeh, Aaron Rizzardo, Andrea Maharaj, Michael Berger, Andrei Krassioukov

Rehabilitation Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Opioids effectively reduce chronic pain, but present significant side effects including opioid-induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied. Methods: We assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55-year-old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively. Results: Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity. Interpretation: Oxycodone/naloxone was effective in managing chronic pain and constipation in the studied case.

Original language	English
Pages (from-to)	453-458
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1002/acn3.51734
State	Published - Mar 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Funding

The authors are grateful for funding from Purdue Pharma (Canada), and also thank Dr. Soshi Samejima and Ms. Tamila Kalimullina for assistance with data analyses.

Funders	Funder number
Purdue Pharma L.P.

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/acn3.51734

Cite this

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abstract = "Background: Opioids effectively reduce chronic pain, but present significant side effects including opioid-induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied. Methods: We assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55-year-old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively. Results: Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity. Interpretation: Oxycodone/naloxone was effective in managing chronic pain and constipation in the studied case.",

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AU - Berger, Michael

AU - Krassioukov, Andrei

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No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

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