Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

Malathi Mathiyazhakan; Yuanxiang Yang; Yibo Liu; Caigang Zhu; Quan Liu; Claus Dieter Ohl; Kam Chiu Tam; Yu Gao; Chenjie Xu

doi:10.1016/j.colsurfb.2014.11.019

Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

Malathi Mathiyazhakan, Yuanxiang Yang, Yibo Liu, Caigang Zhu, Quan Liu, Claus Dieter Ohl, Kam Chiu Tam, Yu Gao, Chenjie Xu

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.

Original language	English
Pages (from-to)	569-574
Number of pages	6
Journal	Colloids and Surfaces B: Biointerfaces
Volume	126
DOIs	https://doi.org/10.1016/j.colsurfb.2014.11.019
State	Published - Feb 1 2015

Bibliographical note

Funding Information:
This work was partially supported by the Tier-1 Academic Research Funds by Singapore Ministry of Education ( RG 64/12 to CX). Cryo-TEM images were acquired with the help of Dr. Andrew Wong and Prof. Sara Sandin. We also thank Dr. Yuanzeng Min and Prof. Bengang Xing for helping us with ICP-MS experiments, Mr. Assaf Cohen for drawing SI Fig. S1.

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

Controlled release
Drug delivery
Exogenous stimuli-responsive nanoparticles
Gold nanoparticles
Microbubble cavitation
Thermal-responsive liposome

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

Access to Document

10.1016/j.colsurfb.2014.11.019

Cite this

@article{0944d8f37721468db2e8b942a6fa2185,

title = "Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation",

abstract = "Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.",

keywords = "Controlled release, Drug delivery, Exogenous stimuli-responsive nanoparticles, Gold nanoparticles, Microbubble cavitation, Thermal-responsive liposome",

author = "Malathi Mathiyazhakan and Yuanxiang Yang and Yibo Liu and Caigang Zhu and Quan Liu and Ohl, {Claus Dieter} and Tam, {Kam Chiu} and Yu Gao and Chenjie Xu",

note = "Funding Information: This work was partially supported by the Tier-1 Academic Research Funds by Singapore Ministry of Education ( RG 64/12 to CX). Cryo-TEM images were acquired with the help of Dr. Andrew Wong and Prof. Sara Sandin. We also thank Dr. Yuanzeng Min and Prof. Bengang Xing for helping us with ICP-MS experiments, Mr. Assaf Cohen for drawing SI Fig. S1. Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.colsurfb.2014.11.019",

language = "English",

volume = "126",

pages = "569--574",

}

TY - JOUR

T1 - Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

AU - Mathiyazhakan, Malathi

AU - Yang, Yuanxiang

AU - Liu, Yibo

AU - Zhu, Caigang

AU - Liu, Quan

AU - Ohl, Claus Dieter

AU - Tam, Kam Chiu

AU - Gao, Yu

AU - Xu, Chenjie

N1 - Funding Information: This work was partially supported by the Tier-1 Academic Research Funds by Singapore Ministry of Education ( RG 64/12 to CX). Cryo-TEM images were acquired with the help of Dr. Andrew Wong and Prof. Sara Sandin. We also thank Dr. Yuanzeng Min and Prof. Bengang Xing for helping us with ICP-MS experiments, Mr. Assaf Cohen for drawing SI Fig. S1. Publisher Copyright: © 2014 Elsevier B.V.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.

AB - Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.

KW - Controlled release

KW - Drug delivery

KW - Exogenous stimuli-responsive nanoparticles

KW - Gold nanoparticles

KW - Microbubble cavitation

KW - Thermal-responsive liposome

UR - http://www.scopus.com/inward/record.url?scp=84923034649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923034649&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfb.2014.11.019

DO - 10.1016/j.colsurfb.2014.11.019

M3 - Article

C2 - 25481686

AN - SCOPUS:84923034649

SN - 0927-7765

VL - 126

SP - 569

EP - 574

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

Non-invasive controlled release from gold nanoparticle integrated photo-responsive liposomes through pulse laser induced microbubble cavitation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this