Drug-carriers, capable of releasing the drug at the target sites upon external stimuli, are attractive for theranostic applications. In recent years, photo-responsive nanoparticles (NPs) have received considerable attention because of their potentials in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the process of development and are unprocurable by the clinics. Here, we demonstrated facile fabrication of these photo-responsive NPs by loading hydrophilic gold NPs within thermo-responsive liposomes. Calcein was used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Furthermore, we characterized their size, morphology, phase transition temperature and stability. Finally, we demonstrated that this photo-triggered release might be due to the membrane disruption caused by microbubble cavitation.
|Number of pages||6|
|Journal||Colloids and Surfaces B: Biointerfaces|
|State||Published - Feb 1 2015|
Bibliographical noteFunding Information:
This work was partially supported by the Tier-1 Academic Research Funds by Singapore Ministry of Education ( RG 64/12 to CX). Cryo-TEM images were acquired with the help of Dr. Andrew Wong and Prof. Sara Sandin. We also thank Dr. Yuanzeng Min and Prof. Bengang Xing for helping us with ICP-MS experiments, Mr. Assaf Cohen for drawing SI Fig. S1.
© 2014 Elsevier B.V.
- Controlled release
- Drug delivery
- Exogenous stimuli-responsive nanoparticles
- Gold nanoparticles
- Microbubble cavitation
- Thermal-responsive liposome
ASJC Scopus subject areas
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry