Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

doi:10.1007/s11065-017-9342-8

Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

Research output: Contribution to journal › Review article › peer-review

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Abstract

In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer’s dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.

Original language	English
Pages (from-to)	245-257
Number of pages	13
Journal	Neuropsychology Review
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s11065-017-9342-8
State	Published - Sep 1 2017

Bibliographical note

Funding Information:
CMS was supported by the Alzheimer Society of Canada (Young Investigator Award #1216). CH was supported by a Salary Award (Chercheur-boursier, Senior) from the Fonds de Recherche du Québec–Santé. AT was supported by BRACE-Alzheimer’s Research (Registered Charity 297965). HH is supported by the AXA Research Fund, the Fondation Université Pierre et Marie Curie and the “Fondation pour la Recherche sur Alzheimer”, Paris, France. The research leading to these results has received funding from the program“Investissements d’avenir” ANR-10-IAIHU-06. The authors are grateful to Dr. Simone Lista for research assistance with completion of this study.

Publisher Copyright:
© 2017, Springer Science+Business Media New York.

Keywords

Alzheimer’s disease
Cognitive interventions
Complementary therapies
Mild cognitive impairment
Treatment outcome

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology

Access to Document

10.1007/s11065-017-9342-8

Cite this

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title = "Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations",

abstract = "In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer{\textquoteright}s dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.",

keywords = "Alzheimer{\textquoteright}s disease, Cognitive interventions, Complementary therapies, Mild cognitive impairment, Treatment outcome",

author = "Smart, {Colette M.} and Karr, {Justin E.} and Areshenkoff, {Corson N.} and Rabin, {Laura A.} and Carol Hudon and Nicola Gates and Ali, {Jordan I.} and Arenaza-Urquijo, {Eider M.} and Buckley, {Rachel F.} and Gael Chetelat and Harald Hampel and Frank Jessen and Marchant, {Natalie L.} and Sikkes, {Sietske A.M.} and Andrea Tales and {van der Flier}, {Wiesje M.} and Linda Wesselman",

note = "Funding Information: CMS was supported by the Alzheimer Society of Canada (Young Investigator Award #1216). CH was supported by a Salary Award (Chercheur-boursier, Senior) from the Fonds de Recherche du Qu{\'e}bec–Sant{\'e}. AT was supported by BRACE-Alzheimer{\textquoteright}s Research (Registered Charity 297965). HH is supported by the AXA Research Fund, the Fondation Universit{\'e} Pierre et Marie Curie and the “Fondation pour la Recherche sur Alzheimer”, Paris, France. The research leading to these results has received funding from the program“Investissements d{\textquoteright}avenir” ANR-10-IAIHU-06. The authors are grateful to Dr. Simone Lista for research assistance with completion of this study. Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media New York.",

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doi = "10.1007/s11065-017-9342-8",

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AU - Areshenkoff, Corson N.

AU - Rabin, Laura A.

AU - Hudon, Carol

AU - Gates, Nicola

AU - Ali, Jordan I.

AU - Arenaza-Urquijo, Eider M.

AU - Buckley, Rachel F.

AU - Chetelat, Gael

AU - Hampel, Harald

AU - Jessen, Frank

AU - Marchant, Natalie L.

AU - Sikkes, Sietske A.M.

AU - Tales, Andrea

AU - van der Flier, Wiesje M.

AU - Wesselman, Linda

N1 - Funding Information: CMS was supported by the Alzheimer Society of Canada (Young Investigator Award #1216). CH was supported by a Salary Award (Chercheur-boursier, Senior) from the Fonds de Recherche du Québec–Santé. AT was supported by BRACE-Alzheimer’s Research (Registered Charity 297965). HH is supported by the AXA Research Fund, the Fondation Université Pierre et Marie Curie and the “Fondation pour la Recherche sur Alzheimer”, Paris, France. The research leading to these results has received funding from the program“Investissements d’avenir” ANR-10-IAIHU-06. The authors are grateful to Dr. Simone Lista for research assistance with completion of this study. Publisher Copyright: © 2017, Springer Science+Business Media New York.

PY - 2017/9/1

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N2 - In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer’s dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.

AB - In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer’s dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline. The objective of this systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, is to examine the benefits of non-pharmacologic intervention (NPI) in persons with SCD. Inclusion criteria were studies of adults aged 55 + with SCD defined using published criteria, receiving NPI or any control condition, with cognitive, behavioural, or psychological outcomes in controlled trails. Published empirical studies were obtained through a standardized search of CINAHL Complete, Cochrane Central Register of Controlled Trials, MEDLINE with Full Text, PsycINFO, and PsycARTICLES, supplemented by a manual retrieval of relevant articles. Study quality and bias was determined using PEDro. Nine studies were included in the review and meta-analysis. A wide range of study quality was observed. Overall, a small effect size was found on cognitive outcomes, greater for cognitive versus other intervention types. The available evidence suggests that NPI may benefit current cognitive function in persons with SCD. Recommendations are provided to improve future trials of NPI in SCD.

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KW - Cognitive interventions

KW - Complementary therapies

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KW - Treatment outcome

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Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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