Non-small-cell lung cancers: A heterogeneous set of diseases

Zhao Chen, Christine M. Fillmore, Peter S. Hammerman, Carla F. Kim, Kwok Kin Wong

Research output: Contribution to journalReview articlepeer-review

1088 Citations (SciVal)


Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have diverse pathological features. During the past decade, in-depth analyses of lung cancer genomes and signalling pathways have further defined NSCLCs as a group of distinct diseases with genetic and cellular heterogeneity. Consequently, an impressive list of potential therapeutic targets was unveiled, drastically altering the clinical evaluation and treatment of patients. Many targeted therapies have been developed with compelling clinical proofs of concept; however, treatment responses are typically short-lived. Further studies of the tumour microenvironment have uncovered new possible avenues to control this deadly disease, including immunotherapy.

Original languageEnglish
Pages (from-to)535-546
Number of pages12
JournalNature Reviews Cancer
Issue number8
StatePublished - Aug 2014

Bibliographical note

Funding Information:
The authors thank United Against Lung Cancer, Thoracic Foundation, Bonnie J Addario Lung Cancer Foundation, Claudia Adams Barr Program For Basic Cancer Research, grant numbers CA122794, CA166480, CA163896, CA154303, CA120964 CA140594.

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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