Abstract
In addition to the essential function of the viral RNA as a template during replication of positive-stranded (+)RNA viruses, the RNA also has crucial non-template functions. These functions during replication include the recruitment of the viral RNA to the site of replication and assembly of the functional viral replicase complex. The RNA recruitment elements are specifically recognized by the viral replication protein, but also affected by host factors such as elongation factor 1A or P-body proteins. The cis-elements for replicase assembly can partially overlap with RNA recruitment elements and they may provide a platform for the assembly of the replicase complex consisting of viral and host proteins. This review focuses on our current knowledge obtained with tombusviruses and other plant viruses. Altogether, understanding of the non-template functions of the viral RNA during viral replication provides new insights into virus-host interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 332-338 |
| Number of pages | 7 |
| Journal | Current Opinion in Virology |
| Volume | 1 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2011 |
Bibliographical note
Funding Information:We thank members of our laboratory for valuable discussions on the areas of this review. We apologize to those colleagues whose work could not be included because of space restrictions. This work was supported by the National Institute of Allergy and Infectious Diseases ( NIH-NIAID AI05767001A1 ) and by the University of Kentucky , awarded to PDN and by a Philip Morris fellowship to KBP.
ASJC Scopus subject areas
- Virology