Abstract
A noncontact diffuse correlation spectroscopy (DCS) probe has been developed using two separated optical paths for the source and detector. This unique design avoids the interference between the source and detector and allows large source-detector separations for deep tissue blood flow measurements. The noncontact probe has been calibrated against a contact probe in a tissue-like phantom solution and human muscle tissues; flow changes concurrently measured by the two probes are highly correlated in both phantom (R2 1/4 0.89, p < 10?5) and real-tissue (R2 1/4 0.77, p < 10?5, n 1/4 9) tests. The noncontact DCS holds promise for measuring blood flow in vulnerable (e.g., pressure ulcer) and soft (e.g., breast) tissues without distorting tissue hemodynamic properties.
| Original language | English |
|---|---|
| Journal | Journal of Biomedical Optics |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
Bibliographical note
Funding Information:The authors thank funding support from the National Institutes of Health (NIH) R01 CA149274 and NIH National Center for Research Resources (NCRR) UL1RR033173.
Funding
The authors thank funding support from the National Institutes of Health (NIH) R01 CA149274 and NIH National Center for Research Resources (NCRR) UL1RR033173.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R01 CA149274 |
| National Center for Research Resources | UL1RR033173 |
Keywords
- Blood flow
- Correlation
- Deep tissue
- Diffuse
- Noncontact
- Spectroscopy
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering