Noncontact optical assessment of spontaneous low-frequency fluctuations of cerebral blood flow in neonatal intraventricular hemorrhage

Mehrana Mohtasebi, Chong Huang, Siavash Mazdeyasna, Brennen Green, Kathryn Saatman, Qiang Cheng, Lei Chen, Guoqiang Yu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Intraventricular hemorrhage (IVH) is the most common neurological complication of prematurity. IVH is a bleeding inside or around ventricles, spaces in the brain containing the cerebrospinal fluid, which occurs as a result of the fragility and immaturity of blood vessels in premature brains. Severe IVH disrupts development of structural and functional connectivity networks, leading to impairments of cerebral development and neurologic deficits. Preterm infants with IVH are prone to alterations in cerebral blood flow (CBF) and associated spontaneous low-frequency fluctuations. However, there are no established noninvasive imaging methods for continuous monitoring of CBF alterations at the bedside in neonatal intensive care units. An innovative CCD/CMOS based speckle contrast diffuse correlation tomography (scDCT) technology has been recently developed in our laboratory, which enables noncontact, noninvasive, and high-density 3D imaging of CBF distributions in deep brain cortex. In the present study, the capability of scDCT technique for noncontact 3D imaging of CBF distributions in a neonatal piglet model of IVH was demonstrated. Moreover, power spectral density analyses of scDCT data were performed to assess alterations in spontaneous low-frequency fluctuations in the resting brain, before and after inducing IVH. IVH resulted in a CBF decrease in deep brain cortex. Resting-state spontaneous low-frequency fluctuations after IVH showed attenuations in all frequencies (0.009–0.08 Hz) compared to the baseline before IVH. In conclusion, scDCT is capable of detecting brain hemodynamic disruptions (reduction in CBF and attenuation in spontaneous low-frequency fluctuations) after IVH, which might be useful for instant management of IVH and associated complications.

Original languageEnglish
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
EditorsV. X. D. Yang, Q. M. Luo, S. K. Mohanty, J. Ding, A. W. Roe, J. M. Kainerstorfer, L. Fu, S. Shoham
ISBN (Electronic)9781510640931
DOIs
StatePublished - 2021
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11629
ISSN (Print)1605-7422

Conference

ConferenceOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics 2021
Country/TerritoryUnited States
CityVirtual, Online
Period3/6/213/11/21

Bibliographical note

Funding Information:
We acknowledge partially financial supports from National Institutes of Health (NIH: COBRE #1P20GM121327, R01-HD101508‐01, R01-EB028792, R01-AG062480, R21‐AG046762, R21-HD091118, R21-NS114771 and R56-NS117587), National Science Foundation (NSF: EPSCoR-1539068), American Heart Association (AHA: 14SDG20480186, 16GRNT30820006) and University of Kentucky Neuroscience Research Priority Area (NRPA) Pilot Grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NSF, AHA or University of Kentucky NRPA Pilot Grant.

Publisher Copyright:
© 2021 SPIE.

Keywords

  • Cerebral blood flow
  • Low-frequency fluctuations
  • Neonatal piglet
  • Optical imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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