Noninvasive and sensitive optical assessment of brain death

Boan Pan, Chong Huang, Xiang Fang, Xiaobo Huang, Ting Li

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O 2 (FIO 2 ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO 2 ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO 2 ]/Δ[Hb] in low-to-high FIO 2 phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO 2 protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.

Original languageEnglish
Article numbere201800240
JournalJournal of Biophotonics
Volume12
Issue number3
DOIs
StatePublished - Mar 2019

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

National Key R&D Programs of China, Grant/ Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023 This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016 -I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJ C32700). information National Key R&D Programs of China, Grant/Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJC32700).

FundersFunder number
CAMS Innovation Fund for Medical Sciences
National Key R&D Programs of China2017YFB1300301, 2017YFB1302305
National Natural Science Fund Projects61675039
Tianjin Key Project18JCZDJ C32700
Chinese Academy of Meteorological Sciences2016-I2M-3-023

    Keywords

    • brain death
    • fraction of inspired O
    • near-infrared spectroscopy
    • oxy-/deoxy-hemoglobin

    ASJC Scopus subject areas

    • General Chemistry
    • General Materials Science
    • General Biochemistry, Genetics and Molecular Biology
    • General Engineering
    • General Physics and Astronomy

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