Noninvasive and sensitive optical assessment of brain death

Boan Pan; Chong Huang; Xiang Fang; Xiaobo Huang; Ting Li

doi:10.1002/jbio.201800240

Noninvasive and sensitive optical assessment of brain death

Boan Pan, Chong Huang, Xiang Fang, Xiaobo Huang, Ting Li

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O ₂ (FIO ₂ ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO ₂ ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO ₂ ]/Δ[Hb] in low-to-high FIO ₂ phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO ₂ protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.

Original language	English
Article number	e201800240
Journal	Journal of Biophotonics
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/jbio.201800240
State	Published - Mar 2019

Bibliographical note

Funding Information:
National Key R&D Programs of China, Grant/ Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023

Funding Information:
This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016 -I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJ C32700).

Funding Information:
information National Key R&D Programs of China, Grant/Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJC32700).

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

brain death
fraction of inspired O
near-infrared spectroscopy
oxy-/deoxy-hemoglobin

ASJC Scopus subject areas

Chemistry (all)
Materials Science (all)
Biochemistry, Genetics and Molecular Biology (all)
Engineering (all)
Physics and Astronomy (all)

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10.1002/jbio.201800240

Cite this

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title = "Noninvasive and sensitive optical assessment of brain death",

abstract = " Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O 2 (FIO 2 ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO 2 ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO 2 ]/Δ[Hb] in low-to-high FIO 2 phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO 2 protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.",

keywords = "brain death, fraction of inspired O, near-infrared spectroscopy, oxy-/deoxy-hemoglobin",

author = "Boan Pan and Chong Huang and Xiang Fang and Xiaobo Huang and Ting Li",

note = "Funding Information: National Key R&D Programs of China, Grant/ Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023 Funding Information: This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016 -I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJ C32700). Funding Information: information National Key R&D Programs of China, Grant/Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJC32700). Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = mar,

doi = "10.1002/jbio.201800240",

language = "English",

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T1 - Noninvasive and sensitive optical assessment of brain death

AU - Pan, Boan

AU - Huang, Chong

AU - Fang, Xiang

AU - Huang, Xiaobo

AU - Li, Ting

N1 - Funding Information: National Key R&D Programs of China, Grant/ Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023 Funding Information: This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016 -I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJ C32700). Funding Information: information National Key R&D Programs of China, Grant/Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJC32700). Publisher Copyright: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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N2 - Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O 2 (FIO 2 ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO 2 ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO 2 ]/Δ[Hb] in low-to-high FIO 2 phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO 2 protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.

AB - Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O 2 (FIO 2 ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO 2 ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO 2 ]/Δ[Hb] in low-to-high FIO 2 phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO 2 protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.

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KW - fraction of inspired O

KW - near-infrared spectroscopy

KW - oxy-/deoxy-hemoglobin

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Noninvasive and sensitive optical assessment of brain death

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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