Abstract
Brain death is an irreversible loss of all brain functions, and the assessment is crucial for organ supply for transplantation. The noninvasive, sensitive, universally available and timely ancillary method to assess brain death has not been established. Here, we attempted to explore a noninvasive way in brain death assessment. Eighteen brain-dead patients and 20 healthy subjects were measured by near-infrared spectroscopy (NIRS), with a multiple-phase protocol at varied fraction of inspired O 2 (FIO 2 ). We found that the concentration changes ratios of oxyhemoglobin to deoxyhemoglobin (Δ[HbO 2 ]/Δ[Hb]) in the cerebral cortex of brain-dead patients were significantly higher than those of healthy subjects. And, the Δ[HbO 2 ]/Δ[Hb] in low-to-high FIO 2 phase was most sensitive to distinguish brain-dead patients from healthy subjects, with a recommended threshold ranged in 1.40~1.50. The innovative incorporation of NIRS and a varied FIO 2 protocol was shown to be a noninvasive and reliable way in assessing brain death. This successful attempt of NIRS application is a help for fast and accurate evaluation of brain death, promptly offering quality-assured donor organs and indicate us a protocol-aided way to expand the use of NIRS.
Original language | English |
---|---|
Article number | e201800240 |
Journal | Journal of Biophotonics |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2019 |
Bibliographical note
Publisher Copyright:© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Funding
National Key R&D Programs of China, Grant/ Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023 This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016 -I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJ C32700). information National Key R&D Programs of China, Grant/Award Number: No. 2017YFB1302305, 2017YFB1300301; National Natural Science Fund Projects, Grant/Award Number: No.61675039; Tianjin Key Project Grant, Grant/Award Number: No.18JCZDJC32700; CAMS Innovation Fund for Medical Sciences, Grant/Award Number: No. 2016-I2M-3-023This work was supported by the National Natural Science Fund Projects (No.61675039), National Key R&D Programs of China (No. 2017YFB1302305, 2017YFB1300301), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-023) and Tianjin Key Project Grant (No. 18JCZDJC32700).
Funders | Funder number |
---|---|
CAMS Innovation Fund for Medical Sciences | |
National Key R&D Programs of China | 2017YFB1300301, 2017YFB1302305 |
National Natural Science Fund Projects | 61675039 |
Tianjin Key Project | 18JCZDJ C32700 |
Chinese Academy of Meteorological Sciences | 2016-I2M-3-023 |
Keywords
- brain death
- fraction of inspired O
- near-infrared spectroscopy
- oxy-/deoxy-hemoglobin
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- General Biochemistry, Genetics and Molecular Biology
- General Engineering
- General Physics and Astronomy