Noninvasive assessment of gastric acid secretion in man: Application of Electrical Impedance Tomography (EIT)

Shafiqul A. Sarker, Dilip Mahalanabis, Pradip K. Bardhan, Nur H. Alam, Khandaker S. Rabbani, Adnan Kiber, Moinuddin Hassan, Shafiqul Islam, George J. Fuchs, Klaus Gyr

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Electrical impedance tomography (EIT) is a tubeless technique that generates tomographic images of gastric resistivity. We investigated the application of EIT to measure gastric acid secretion. Nineteen normal subjects underwent a standard intubation test. Basal acid output (BAO) and stimulated acid output (SAG) (millimoles per hour) were measured before and after pentagastrin, respectively. On a different day, EIT was performed before (basal) and after pentagastrin (stimulated). The changes in impedance over time were measured and the area under the curve (AUC) was calculated. Both the tests were repeated in 13 subjects after omeprazole treatment. As in the intubation test, there was the expected increase in AUC value after pentagastrin (basal vs stimulated; 1.2 ± 2.8 vs 731 ± 297, P < 0.0001). A significant fall in acid output and AUC following omeprazole pretreatment was observed (without vs with omeprazole; 20.5 ± 5.7 vs 0.03 ± 0.06 P < 0.0001 for intubation test and 731 ± 297 vs 44 ± 172, P < 0.0001 for EIT). There was a significant correlation between SAO and the ΔAUC with (r = 0.65 P < 0.001) or without (r = 0.95, P < 0.001) omeprazole and in all the experiments (r = 0.87, p < 0.001). This study demonstrates the predictable change of gastric impedance and may be useful as a noninvasive test for measuring gastric acid secretion.

Original languageEnglish
Pages (from-to)1804-1809
Number of pages6
JournalDigestive Diseases and Sciences
Issue number8
StatePublished - 1997

Bibliographical note

Funding Information:
This research was supported by the Swiss Development Cooperation (SDC) and the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B). The IC-DDR,B is supported by countries and agencies that share its concern for the health problems of developing countries. Current donors include: the aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Denmark, Germany, Japan, the Netherlands, Norway, Saudi Arabia, Sri Lanka, Sweden, Switzerland, Thailand, the United Kingdom, and the United States; international organizations including the Arab Gulf Fund, Asian Development Bank, European Union, the United Nations Children’s Fund (UNICEF), the United Nations Development Programme (UNDP), the United Nations Fund for Population Activities (UNFPA), and the World Health Organization (WHO); private foundations including the Aga Khan Foundation, Child Health Foundation (CHF), Ford Foundation, Population Council, Rockefeller Foundation and the Sasakawa Foundation; and private organizations including American Express Bank, Bayer A.G., CARE, Family Health International, Helen Keller International, the Johns Hopkins University, Macro International, New England Medical Centre, Procter Gamble, RAND Corporation, SANDOZ, Swiss Red Cross, the University of Alabama at Birmingham, the University of Iowa, Wander A.G., and others. We gratefully acknowledge the help of Dr. Rashed-uzzaman Shah for his help in the study.


  • Electrical impedance tomography
  • Gastric acid output
  • Intubation test
  • Omeprazole

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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