Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study

Ulas Sunar; Harry Quon; Turgut Durduran; Jun Zhang; Juan Du; Chao Zhou; Guoqiang Yu; Regine Choe; Alex Kilger; Robert Lustig; Laurie Loevner; Shoko Nioka; Britton Chance; Arjun G. Yodh

doi:10.1117/1.2397548

Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study

Ulas Sunar, Harry Quon, Turgut Durduran, Jun Zhang, Juan Du, Chao Zhou, Guoqiang Yu, Regine Choe, Alex Kilger, Robert Lustig, Laurie Loevner, Shoko Nioka, Britton Chance, Arjun G. Yodh

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO₂), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, St O₂, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO₂, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO₂ increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0) [μM] to (73.3 ±8.3) [μM] at the end of the second week and to (63.0±8.1) [μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.

Original language	English
Article number	064021
Journal	Journal of Biomedical Optics
Volume	11
Issue number	6
DOIs	https://doi.org/10.1117/1.2397548
State	Published - Nov 2006

Bibliographical note

Funding Information:
This research is supported by National Institutes of Health grants HL-077699-01 and CA-87971. We thank S. Kim and H. Poptani for useful discussions. We also thank the Radiation Physics Division of Hospital of the University of Pennsylvania for providing CT, MRI, and PET scans of our head and neck patients.

Keywords

Blood flow
Diffuse optics
Head and neck tumors
Therapy monitoring
Tissue oxygenation

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.2397548

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Sunar, U., Quon, H., Durduran, T., Zhang, J., Du, J., Zhou, C., Yu, G., Choe, R., Kilger, A., Lustig, R., Loevner, L., Nioka, S., Chance, B., & Yodh, A. G. (2006). Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study. Journal of Biomedical Optics, 11(6), Article 064021. https://doi.org/10.1117/1.2397548

@article{baeb4e7574024525a2eb05cf39da127d,

title = "Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study",

abstract = "This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO2), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, St O2, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO2, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO2 increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0) [μM] to (73.3 ±8.3) [μM] at the end of the second week and to (63.0±8.1) [μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.",

keywords = "Blood flow, Diffuse optics, Head and neck tumors, Therapy monitoring, Tissue oxygenation",

author = "Ulas Sunar and Harry Quon and Turgut Durduran and Jun Zhang and Juan Du and Chao Zhou and Guoqiang Yu and Regine Choe and Alex Kilger and Robert Lustig and Laurie Loevner and Shoko Nioka and Britton Chance and Yodh, {Arjun G.}",

note = "Funding Information: This research is supported by National Institutes of Health grants HL-077699-01 and CA-87971. We thank S. Kim and H. Poptani for useful discussions. We also thank the Radiation Physics Division of Hospital of the University of Pennsylvania for providing CT, MRI, and PET scans of our head and neck patients.",

year = "2006",

month = nov,

doi = "10.1117/1.2397548",

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Sunar, U, Quon, H, Durduran, T, Zhang, J, Du, J, Zhou, C, Yu, G, Choe, R, Kilger, A, Lustig, R, Loevner, L, Nioka, S, Chance, B & Yodh, AG 2006, 'Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study', Journal of Biomedical Optics, vol. 11, no. 6, 064021. https://doi.org/10.1117/1.2397548

TY - JOUR

T1 - Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors

T2 - A pilot study

AU - Sunar, Ulas

AU - Quon, Harry

AU - Durduran, Turgut

AU - Zhang, Jun

AU - Du, Juan

AU - Zhou, Chao

AU - Yu, Guoqiang

AU - Choe, Regine

AU - Kilger, Alex

AU - Lustig, Robert

AU - Loevner, Laurie

AU - Nioka, Shoko

AU - Chance, Britton

AU - Yodh, Arjun G.

N1 - Funding Information: This research is supported by National Institutes of Health grants HL-077699-01 and CA-87971. We thank S. Kim and H. Poptani for useful discussions. We also thank the Radiation Physics Division of Hospital of the University of Pennsylvania for providing CT, MRI, and PET scans of our head and neck patients.

PY - 2006/11

Y1 - 2006/11

N2 - This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO2), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, St O2, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO2, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO2 increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0) [μM] to (73.3 ±8.3) [μM] at the end of the second week and to (63.0±8.1) [μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.

AB - This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO2), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, St O2, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO2, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO2 increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0) [μM] to (73.3 ±8.3) [μM] at the end of the second week and to (63.0±8.1) [μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.

KW - Blood flow

KW - Diffuse optics

KW - Head and neck tumors

KW - Therapy monitoring

KW - Tissue oxygenation

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SN - 1083-3668

VL - 11

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

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ER -

Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: A pilot study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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