Abstract
We modified and adapted a novel noncontact speckle contrast diffuse correlation tomography (scDCT) system, developed in our laboratory, for noninvasive 3D imaging of blood flow distributions in small animals and large human tissue volumes. The new system has the flexibility of selecting small and large regions of interest (ROIs) with different imaging depths for the use in both the small mouse head and large human mastectomy skin flaps. The capability of the upgraded scDCT system was demonstrated by continuous imaging of cerebral blood flow (CBF) changes in a small mouse head during sequential common carotid artery ligations and blood flow distributions in human mastectomy skin flaps during surgery. As expected, arterial occlusions resulted in substantial CBF decreases in deep brain tissues of the mouse. Spatial heterogeneity existed, and lower blood flow values were observed around the incision area of mastectomy skin flaps. The noncontact scDCT system with flexible ROIs and imaging depths has the potential to be used in many preclinical and clinical settings for noninvasive assessment of tissue hemodynamics and viability.
Original language | English |
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Title of host publication | 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 |
Pages | 129-134 |
Number of pages | 6 |
ISBN (Electronic) | 9781538675687 |
DOIs | |
State | Published - Jul 2 2018 |
Event | 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 - Louisville, United States Duration: Dec 6 2018 → Dec 8 2018 |
Publication series
Name | 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 |
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Conference
Conference | 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 |
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Country/Territory | United States |
City | Louisville |
Period | 12/6/18 → 12/8/18 |
Bibliographical note
Publisher Copyright:© 2018 IEEE.
Funding
ACKNOWLEDGMENT We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.). We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.).
Funders | Funder number |
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National Science Foundation/EPSCoR | 1539068 |
The University of Kentucky College of Engineering | |
National Institutes of Health (NIH) | R01-CA149274, R21-AR062356, R21-HD091118 |
American Heart Association | 16GRNT0820006, 3048112770 |
Plastic Surgery Foundation | |
National Science Foundation (NSF) |
Keywords
- blood flow imaging
- human mastectomy skin flap
- mouse brain
- speckle contrast diffuse correlation tomography
ASJC Scopus subject areas
- Signal Processing
- Computer Science Applications
- Computer Networks and Communications