Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans

Siavash Mazdeyasna, Chong Huang, Mingjun Zhoa, Alisha R. Bonaroti, Kathryn Saatman, Lei Chen, Elie G.Abu Jawdeh, Henrietta S. Bada, Brandon A. Miller, Lesley Wong, Guoqiang Yu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We modified and adapted a novel noncontact speckle contrast diffuse correlation tomography (scDCT) system, developed in our laboratory, for noninvasive 3D imaging of blood flow distributions in small animals and large human tissue volumes. The new system has the flexibility of selecting small and large regions of interest (ROIs) with different imaging depths for the use in both the small mouse head and large human mastectomy skin flaps. The capability of the upgraded scDCT system was demonstrated by continuous imaging of cerebral blood flow (CBF) changes in a small mouse head during sequential common carotid artery ligations and blood flow distributions in human mastectomy skin flaps during surgery. As expected, arterial occlusions resulted in substantial CBF decreases in deep brain tissues of the mouse. Spatial heterogeneity existed, and lower blood flow values were observed around the incision area of mastectomy skin flaps. The noncontact scDCT system with flexible ROIs and imaging depths has the potential to be used in many preclinical and clinical settings for noninvasive assessment of tissue hemodynamics and viability.

Original languageEnglish
Title of host publication2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Pages441-446
Number of pages6
ISBN (Electronic)9781538675687
DOIs
StatePublished - Feb 14 2019
Event2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 - Louisville, United States
Duration: Dec 6 2018Dec 8 2018

Publication series

Name2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018

Conference

Conference2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Country/TerritoryUnited States
CityLouisville
Period12/6/1812/8/18

Bibliographical note

Funding Information:
ACKNOWLEDGMENT We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.).

Funding Information:
We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.).

Publisher Copyright:
© 2018 IEEE.

Keywords

  • blood flow imaging
  • human mastectomy skin flap
  • mouse brain
  • speckle contrast diffuse correlation tomography

ASJC Scopus subject areas

  • Signal Processing
  • Computer Science Applications
  • Computer Networks and Communications

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