Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans

Siavash Mazdeyasna; Chong Huang; Mingjun Zhoa; Alisha R. Bonaroti; Kathryn Saatman; Lei Chen; Elie G.Abu Jawdeh; Henrietta S. Bada; Brandon A. Miller; Lesley Wong; Guoqiang Yu

doi:10.1109/ISSPIT.2018.8642638

Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans

Siavash Mazdeyasna, Chong Huang, Mingjun Zhoa, Alisha R. Bonaroti, Kathryn Saatman, Lei Chen, Elie G.Abu Jawdeh, Henrietta S. Bada, Brandon A. Miller, Lesley Wong, Guoqiang Yu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We modified and adapted a novel noncontact speckle contrast diffuse correlation tomography (scDCT) system, developed in our laboratory, for noninvasive 3D imaging of blood flow distributions in small animals and large human tissue volumes. The new system has the flexibility of selecting small and large regions of interest (ROIs) with different imaging depths for the use in both the small mouse head and large human mastectomy skin flaps. The capability of the upgraded scDCT system was demonstrated by continuous imaging of cerebral blood flow (CBF) changes in a small mouse head during sequential common carotid artery ligations and blood flow distributions in human mastectomy skin flaps during surgery. As expected, arterial occlusions resulted in substantial CBF decreases in deep brain tissues of the mouse. Spatial heterogeneity existed, and lower blood flow values were observed around the incision area of mastectomy skin flaps. The noncontact scDCT system with flexible ROIs and imaging depths has the potential to be used in many preclinical and clinical settings for noninvasive assessment of tissue hemodynamics and viability.

Original language	English
Title of host publication	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Pages	441-446
Number of pages	6
ISBN (Electronic)	9781538675687
DOIs	https://doi.org/10.1109/ISSPIT.2018.8642638
State	Published - Jul 2 2018
Event	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 - Louisville, United States Duration: Dec 6 2018 → Dec 8 2018

Publication series

Name	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018

Conference

Conference	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Country/Territory	United States
City	Louisville
Period	12/6/18 → 12/8/18

Bibliographical note

Publisher Copyright:
© 2018 IEEE.

Funding

ACKNOWLEDGMENT We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.). We acknowledge support from the National Institutes of Health (NIH) R01-CA149274 (G.Y.), R21-AR062356 (G.Y.), R21-HD091118 (G.Y.), American Heart Association Grant-In-Aid 16GRNT0820006 (G.Y.), National Endowment for Plastic Surgery, Plastic Surgery Foundation 3048112770 (L.W. and G.Y.), National Science Foundation EPSCoR #1539068 (G.Y), and the Halcomb Fellowship in Medicine and Engineering at the University of the Kentucky (S. M.).

Funders	Funder number
National Science Foundation/EPSCoR	1539068
The University of Kentucky College of Engineering
National Institutes of Health (NIH)	R01-CA149274, R21-AR062356, R21-HD091118
American Heart Association	16GRNT0820006, 3048112770
Plastic Surgery Foundation
National Science Foundation (NSF)

Keywords

blood flow imaging
human mastectomy skin flap
mouse brain
speckle contrast diffuse correlation tomography

ASJC Scopus subject areas

Signal Processing
Computer Science Applications
Computer Networks and Communications

Access to Document

10.1109/ISSPIT.2018.8642638

Cite this

Mazdeyasna, S., Huang, C., Zhoa, M., Bonaroti, A. R., Saatman, K., Chen, L., Jawdeh, E. G. A., Bada, H. S., Miller, B. A., Wong, L., & Yu, G. (2018). Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans. In 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 (pp. 441-446). Article 8642638 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018). https://doi.org/10.1109/ISSPIT.2018.8642638

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abstract = "We modified and adapted a novel noncontact speckle contrast diffuse correlation tomography (scDCT) system, developed in our laboratory, for noninvasive 3D imaging of blood flow distributions in small animals and large human tissue volumes. The new system has the flexibility of selecting small and large regions of interest (ROIs) with different imaging depths for the use in both the small mouse head and large human mastectomy skin flaps. The capability of the upgraded scDCT system was demonstrated by continuous imaging of cerebral blood flow (CBF) changes in a small mouse head during sequential common carotid artery ligations and blood flow distributions in human mastectomy skin flaps during surgery. As expected, arterial occlusions resulted in substantial CBF decreases in deep brain tissues of the mouse. Spatial heterogeneity existed, and lower blood flow values were observed around the incision area of mastectomy skin flaps. The noncontact scDCT system with flexible ROIs and imaging depths has the potential to be used in many preclinical and clinical settings for noninvasive assessment of tissue hemodynamics and viability.",

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author = "Siavash Mazdeyasna and Chong Huang and Mingjun Zhoa and Bonaroti, {Alisha R.} and Kathryn Saatman and Lei Chen and Jawdeh, {Elie G.Abu} and Bada, {Henrietta S.} and Miller, {Brandon A.} and Lesley Wong and Guoqiang Yu",

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doi = "10.1109/ISSPIT.2018.8642638",

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Mazdeyasna, S, Huang, C, Zhoa, M, Bonaroti, AR, Saatman, K , Chen, L, Jawdeh, EGA, Bada, HS, Miller, BA, Wong, L & Yu, G 2018, Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans. in 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018., 8642638, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, pp. 441-446, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, Louisville, United States, 12/6/18. https://doi.org/10.1109/ISSPIT.2018.8642638

Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans. / Mazdeyasna, Siavash; Huang, Chong; Zhoa, Mingjun et al.
2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018. 2018. p. 441-446 8642638 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - We modified and adapted a novel noncontact speckle contrast diffuse correlation tomography (scDCT) system, developed in our laboratory, for noninvasive 3D imaging of blood flow distributions in small animals and large human tissue volumes. The new system has the flexibility of selecting small and large regions of interest (ROIs) with different imaging depths for the use in both the small mouse head and large human mastectomy skin flaps. The capability of the upgraded scDCT system was demonstrated by continuous imaging of cerebral blood flow (CBF) changes in a small mouse head during sequential common carotid artery ligations and blood flow distributions in human mastectomy skin flaps during surgery. As expected, arterial occlusions resulted in substantial CBF decreases in deep brain tissues of the mouse. Spatial heterogeneity existed, and lower blood flow values were observed around the incision area of mastectomy skin flaps. The noncontact scDCT system with flexible ROIs and imaging depths has the potential to be used in many preclinical and clinical settings for noninvasive assessment of tissue hemodynamics and viability.

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Mazdeyasna S, Huang C, Zhoa M, Bonaroti AR, Saatman K , Chen L et al. Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans. In 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018. 2018. p. 441-446. 8642638. (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018). doi: 10.1109/ISSPIT.2018.8642638

Noninvasive Noncontact 3D Optical Imaging of Blood Flow Distributions in Animals and Humans

Abstract

Publication series

Conference

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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