Norepinephrine depletion impairs motor recovery following sensorimotor cortex injury in the rat

Larry B. Goldstein, Andrea Coviello, Gerald D. Miller, James N. Davis

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Beam-walking in the rat provides a method for investigating the effects of drugs on motor recovery following unilateral injury to the sensorimotor cortex. In the present experiment, the impact of norepinephrine depletion on beam-walking recovery was investigated. Groups of rats were first given either the neurotoxin DSP-4 or saline. Two weeks later, the animals were trained at the beam-walking task. Rats were then subjected to either a unilateral sensorimotor cortex lesion or sham operation. Recovery of beam-walking performance was measured over the next 12 days. Pretreatment with DSP-4 significantly slowed the rate of recovery but did not significantly affect sham-operated rats. Norepinephrine was significantly diminished in both lesioned and sham-operated rats that had been given DSP-4. These results are consistent with the hypothesis that recovery of beam-walking in the rat is mediated, at least in part, through noradrenergic neurons.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalRestorative Neurology and Neuroscience
Issue number1
StatePublished - 1991


  • Beam-walking
  • Brain injury
  • Cortical lesion
  • DSP-4
  • Motor recovery
  • Noradrenaline
  • Rat
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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