Norepinephrine Depletion in the Spinal Cord Gray Matter of Rats with Experimental Allergic Encephalomyelitis

S. R. White, R. K. Bhatnagar, M. T. Bardo

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Norepinephrine and dopamine concentrations were determined by radioenzymatic assay in discrete gray matter regions of the spinal cords of rats with experimental allergic encephalomyelitis (EAE). Norepinephrine was depleted in most spinal cord regions of EAE rats compared with controls, whereas dopamine depletion in EAE rats was restricted to the cervical dorsal horn. There was a rostrocaudal gradient of norepinephrine reduction in the spinal cords of the EAE rats with most severe depletion in the lumbar region. The results of this experiment confirmed recent anatomical observations that suggested that catecholamine‐fluorescent axons and terminals were damaged in spinal cords of rats with EAE.

Original languageEnglish
Pages (from-to)1771-1773
Number of pages3
JournalJournal of Neurochemistry
Volume40
Issue number6
DOIs
StatePublished - Jun 1983

Keywords

  • Dopamine
  • Experimental allergic encephalomyelitis.
  • Norepinephrine
  • Spinal cord

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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