Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Somayeh Gholami; Francesco Longo; Sara Shahzadeh; Hassan Ali Nedaie; Ryan Sharp; Ali S.Meigooni

doi:10.1016/j.rpor.2020.09.002

Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Somayeh Gholami
, Francesco Longo
, Sara Shahzadeh
, Hassan Ali Nedaie
, Ryan Sharp
, Ali S.Meigooni

Radiation Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques. Materials and Methods: The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam. Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V₂₀), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom. Results: The results show that the MLD and V₂₀ were lower for MR-linac RT. The largest reduction of MLD and V₂₀ for MR-linac RT configurations were 5 Gy and 29.3%, respectively. Conclusion: MR-linac RT may result in lower NLT complications when compared to conventional RT.

Original language	English
Pages (from-to)	961-968
Number of pages	8
Journal	Reports of Practical Oncology and Radiotherapy
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.rpor.2020.09.002
State	Published - Nov 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Greater Poland Cancer Centre

Funding

This research has been supported by Tehran University of Medical Sciences and Health Services with grant number 97-01-207-38000.

Funders	Funder number
Tehran University of Medical Sciences and Health Services	97-01-207-38000

Keywords

Geant4 toolkit
MR-linac
Normal lung tissue complications
XCAT digital phantom

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.rpor.2020.09.002

Cite this

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title = "Normal lung tissue complication probability in MR-Linac and conventional radiotherapy",

abstract = "Purpose: To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques. Materials and Methods: The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam. Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom. Results: The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3\%, respectively. Conclusion: MR-linac RT may result in lower NLT complications when compared to conventional RT.",

keywords = "Geant4 toolkit, MR-linac, Normal lung tissue complications, XCAT digital phantom",

author = "Somayeh Gholami and Francesco Longo and Sara Shahzadeh and Nedaie, \{Hassan Ali\} and Ryan Sharp and Ali S.Meigooni",

note = "Publisher Copyright: {\textcopyright} 2020 Greater Poland Cancer Centre",

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doi = "10.1016/j.rpor.2020.09.002",

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T1 - Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

AU - Gholami, Somayeh

AU - Longo, Francesco

AU - Shahzadeh, Sara

AU - Nedaie, Hassan Ali

AU - Sharp, Ryan

AU - S.Meigooni, Ali

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Purpose: To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques. Materials and Methods: The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam. Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom. Results: The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively. Conclusion: MR-linac RT may result in lower NLT complications when compared to conventional RT.

AB - Purpose: To study normal lung tissue (NLT) complications in magnetic resonance (MR) image based linac and conventional radiotherapy (RT) techniques. Materials and Methods: The Geant4 toolkit was used to simulate a 6 MV photon beam. A homogenous magnetic field of 1.5 Tesla (T) was applied in both perpendicular and parallel directions relative to the radiation beam. Analysis of the NLT complications was assessed according to the normal lung tissue complication probability (NTCP), the mean lung dose (MLD), and percentage of the lung volume receiving doses greater than 20 Gy (V20), using a sample set of CT images generated from a commercially available 4D-XCAT digital phantom. Results: The results show that the MLD and V20 were lower for MR-linac RT. The largest reduction of MLD and V20 for MR-linac RT configurations were 5 Gy and 29.3%, respectively. Conclusion: MR-linac RT may result in lower NLT complications when compared to conventional RT.

KW - Geant4 toolkit

KW - MR-linac

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KW - XCAT digital phantom

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Normal lung tissue complication probability in MR-Linac and conventional radiotherapy

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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