Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure

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13 Scopus citations

Abstract

Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.

Original languageEnglish
Pages (from-to)511-513
Number of pages3
JournalPediatric Pulmonology
Volume43
Issue number5
DOIs
StatePublished - May 2008

Keywords

  • Betalactam antibiotics
  • Continuous infusion
  • Cystic fibrosis
  • Eradication
  • Pseudomonas aeruginosa
  • Tobramycin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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