Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure

Don Hayes; Jamshed F. Kanga; Michael I. Anstead; Robert J. Kuhn

doi:10.1002/ppul.20791

Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure

Don Hayes, Jamshed F. Kanga, Michael I. Anstead, Robert J. Kuhn

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.

Original language	English
Pages (from-to)	511-513
Number of pages	3
Journal	Pediatric Pulmonology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/ppul.20791
State	Published - May 2008

Keywords

Betalactam antibiotics
Continuous infusion
Cystic fibrosis
Eradication
Pseudomonas aeruginosa
Tobramycin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

Access to Document

10.1002/ppul.20791

Cite this

@article{573ba2a5c91045f5a0ef4f32b70c6a36,

title = "Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure",

abstract = "Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.",

keywords = "Betalactam antibiotics, Continuous infusion, Cystic fibrosis, Eradication, Pseudomonas aeruginosa, Tobramycin",

author = "Don Hayes and Kanga, {Jamshed F.} and Anstead, {Michael I.} and Kuhn, {Robert J.}",

year = "2008",

month = may,

doi = "10.1002/ppul.20791",

language = "English",

volume = "43",

pages = "511--513",

number = "5",

}

TY - JOUR

T1 - Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure

AU - Hayes, Don

AU - Kanga, Jamshed F.

AU - Anstead, Michael I.

AU - Kuhn, Robert J.

PY - 2008/5

Y1 - 2008/5

N2 - Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.

AB - Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.

KW - Betalactam antibiotics

KW - Continuous infusion

KW - Cystic fibrosis

KW - Eradication

KW - Pseudomonas aeruginosa

KW - Tobramycin

UR - http://www.scopus.com/inward/record.url?scp=43249101969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43249101969&partnerID=8YFLogxK

U2 - 10.1002/ppul.20791

DO - 10.1002/ppul.20791

M3 - Article

C2 - 18383117

AN - SCOPUS:43249101969

SN - 8755-6863

VL - 43

SP - 511

EP - 513

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

IS - 5

ER -

Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this