TY - JOUR
T1 - Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone
AU - Albayati, Zaineb A.F.
AU - Sunkara, Manjula
AU - Schmidt-Malan, Suzannah M.
AU - Karau, Melissa J.
AU - Morris, Andrew J.
AU - Steckelberg, James M.
AU - Patel, Robin
AU - Breen, Philip J.
AU - Smeltzer, Mark S.
AU - Taylor, K. Grant
AU - Merten, Kevyn E.
AU - Pierce, William M.
AU - Crooks, Peter A.
N1 - Publisher Copyright:
© 2016, American Society for Microbiology. All Rights Reserved.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
AB - We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
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U2 - 10.1128/AAC.01609-15
DO - 10.1128/AAC.01609-15
M3 - Article
C2 - 26666918
AN - SCOPUS:84960448629
SN - 0066-4804
VL - 60
SP - 1855
EP - 1868
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -
