Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Zaineb A.F. Albayati; Manjula Sunkara; Suzannah M. Schmidt-Malan; Melissa J. Karau; Andrew J. Morris; James M. Steckelberg; Robin Patel; Philip J. Breen; Mark S. Smeltzer; K. Grant Taylor; Kevyn E. Merten; William M. Pierce; Peter A. Crooks

doi:10.1128/AAC.01609-15

Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Zaineb A.F. Albayati, Manjula Sunkara, Suzannah M. Schmidt-Malan, Melissa J. Karau, Andrew J. Morris, James M. Steckelberg, Robin Patel, Philip J. Breen, Mark S. Smeltzer, K. Grant Taylor, Kevyn E. Merten, William M. Pierce, Peter A. Crooks

Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

Original language	English
Pages (from-to)	1855-1868
Number of pages	14
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01609-15
State	Published - Mar 1 2016

Bibliographical note

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© 2016, American Society for Microbiology. All Rights Reserved.

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01609-15

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Albayati, Z. A. F., Sunkara, M., Schmidt-Malan, S. M., Karau, M. J., Morris, A. J., Steckelberg, J. M., Patel, R., Breen, P. J., Smeltzer, M. S., Taylor, K. G., Merten, K. E., Pierce, W. M., & Crooks, P. A. (2016). Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrobial Agents and Chemotherapy, 60(3), 1855-1868. https://doi.org/10.1128/AAC.01609-15

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AU - Morris, Andrew J.

AU - Steckelberg, James M.

AU - Patel, Robin

AU - Breen, Philip J.

AU - Smeltzer, Mark S.

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AU - Merten, Kevyn E.

AU - Pierce, William M.

AU - Crooks, Peter A.

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Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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