We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
|Number of pages
|Antimicrobial Agents and Chemotherapy
|Published - Mar 1 2016
Bibliographical notePublisher Copyright:
© 2016, American Society for Microbiology. All Rights Reserved.
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases