Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report

Dana J. Holger; Ashlan J. Kunz Coyne; Jing J. Zhao; Avnish Sandhu; Hossein Salimnia; Michael J. Rybak

doi:10.1093/ofid/ofac092

Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report

Dana J. Holger, Ashlan J. Kunz Coyne, Jing J. Zhao, Avnish Sandhu, Hossein Salimnia, Michael J. Rybak

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.

Original language	English
Article number	ofac092
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofac092
State	Published - Apr 1 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

Acinetobacter baumannii
antimicrobial resistance
combination therapy
pneumonia
sulbactam-durlobactam

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofac092

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title = "Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report",

abstract = "We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.",

keywords = "Acinetobacter baumannii, antimicrobial resistance, combination therapy, pneumonia, sulbactam-durlobactam",

author = "Holger, {Dana J.} and {Kunz Coyne}, {Ashlan J.} and Zhao, {Jing J.} and Avnish Sandhu and Hossein Salimnia and Rybak, {Michael J.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Holger, Dana J.

AU - Kunz Coyne, Ashlan J.

AU - Zhao, Jing J.

AU - Sandhu, Avnish

AU - Salimnia, Hossein

AU - Rybak, Michael J.

PY - 2022/4/1

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N2 - We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.

AB - We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.

KW - Acinetobacter baumannii

KW - antimicrobial resistance

KW - combination therapy

KW - pneumonia

KW - sulbactam-durlobactam

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Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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