Novel Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Necrotizing Pneumonia Complicated by Empyema: A Case Report

Dana J. Holger, Ashlan J. Kunz Coyne, Jing J. Zhao, Avnish Sandhu, Hossein Salimnia, Michael J. Rybak

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, and synergy analysis guided the selection of rational combination antimicrobial therapy.

Original languageEnglish
Article numberofac092
JournalOpen Forum Infectious Diseases
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

  • Acinetobacter baumannii
  • antimicrobial resistance
  • combination therapy
  • pneumonia
  • sulbactam-durlobactam

ASJC Scopus subject areas

  • Oncology
  • Infectious Diseases

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