Novel exploitation of autophagy by tombusviruses

Peter D. Nagy, Judit Pogany, Yuanrong Kang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Positive-strand (+)RNA viruses are major pathogens of humans, animals and plants. This review summarizes the complex interplay between the host autophagy pathway and Tomato bushy stunt virus (TBSV) replication. Recent discoveries with TBSV have revealed virus-driven exploitation of autophagy in multiple ways that contributes to the unique phospholipid composition of viral replication organellar (VROs) membranes. Viral replication protein-driven subversion of phagophore membranes, recruitment of ATG2 bulk lipid transfer protein to enrich phosphatidylethanolamine and phosphatidylserine in VROs, recruitment of VPS34 PI3K to produce PI(3)P; and ATG11-facilitated formation of stable viral membrane contact sites contributes to VRO membrane proliferation. Recruitment of autophagy core proteins to vir-NBR1 bodies within vir-condensates associated with VROs results in dampened antiviral degradation by autophagy. Overall, TBSV intricate interplay with the autophagy machinery highlights the importance of lipid dynamics in viral life cycles and points toward potential directions for therapeutic intervention.

Original languageEnglish
Article number110363
JournalVirology
Volume603
DOIs
StatePublished - Feb 2025

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

Funding

We thank Drs. Wenwu Lin and Shifeng Zhu for comments on the manuscript. We thank the reviewers for valuable suggestions to improve the paper. This work was supported by the National Science Foundation (IOS-1922895), USDA (NIFA, 2020-70410-32901) and a USDA hatch grant (KY012042) to PDN.

FundersFunder number
U.S. Department of Agriculture
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of ChinaIOS-1922895
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China
US Department of Agriculture National Institute of Food and Agriculture, Agriculture and Food Research Initiative2020-70410-32901, KY012042
US Department of Agriculture National Institute of Food and Agriculture, Agriculture and Food Research Initiative

    Keywords

    • Dependency factor
    • Host factor
    • Lipid transfer protein
    • Nicotiana benthamiana
    • Phospholipids
    • Replication
    • Tomato bushy stunt virus
    • Virus-host interaction
    • Yeast

    ASJC Scopus subject areas

    • Virology

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