Novel Genetically Engineered Tetracenomycins

Heinrich Decker; Sabine Haag; Györgyi Udvarnoki; Jürgen Rohr

doi:10.1002/anie.199511071

Novel Genetically Engineered Tetracenomycins

Heinrich Decker, Sabine Haag, Györgyi Udvarnoki, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Genetically engineered hybrid strains, in which the genes of the urdamycin‐producer Streptomyce fradiae are combined with some of the biosynthetic genes of the elloramycin‐producer Streptomyces olivaceus or the genes of the tetracenomycin‐producer Streptomyces glaucescens, assemble novel hybrid antibiotics of the tetracenomycin type. The results prove that this combinatorial biosynthesis method may be a useful alternative for the production of new natural products which can then be screened.

Original language	English
Pages (from-to)	1107-1110
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	34
Issue number	10
DOIs	https://doi.org/10.1002/anie.199511071
State	Published - Jun 2 1995

Keywords

biosynthesis
gene technology
polyketides
tetracenomycins

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.199511071

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AB - Genetically engineered hybrid strains, in which the genes of the urdamycin‐producer Streptomyce fradiae are combined with some of the biosynthetic genes of the elloramycin‐producer Streptomyces olivaceus or the genes of the tetracenomycin‐producer Streptomyces glaucescens, assemble novel hybrid antibiotics of the tetracenomycin type. The results prove that this combinatorial biosynthesis method may be a useful alternative for the production of new natural products which can then be screened.

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KW - gene technology

KW - polyketides

KW - tetracenomycins

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Novel Genetically Engineered Tetracenomycins

Abstract

Keywords

ASJC Scopus subject areas

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