Novel Genetically Engineered Tetracenomycins

Heinrich Decker, Sabine Haag, Györgyi Udvarnoki, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Genetically engineered hybrid strains, in which the genes of the urdamycin‐producer Streptomyce fradiae are combined with some of the biosynthetic genes of the elloramycin‐producer Streptomyces olivaceus or the genes of the tetracenomycin‐producer Streptomyces glaucescens, assemble novel hybrid antibiotics of the tetracenomycin type. The results prove that this combinatorial biosynthesis method may be a useful alternative for the production of new natural products which can then be screened.

Original languageEnglish
Pages (from-to)1107-1110
Number of pages4
JournalAngewandte Chemie International Edition in English
Issue number10
StatePublished - Jun 2 1995


  • biosynthesis
  • gene technology
  • polyketides
  • tetracenomycins

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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