Spurred by advances in understanding the molecular basis of thrombosis, this issue of the Journal of Thrombosis and Thrombolysis is devoted to exploring aspects of novel paradigms and their potential impact on diagnosis and treatment. Complex interplay between blood and vascular cells, inflammation, and pro- and anti-coagulant pathways determines the formation and stability of arterial and venous thrombosis. A causal role for inflammation in coronary artery disease is currently being tested in large clinical trials. Basic science observations implicate inflammation in venous thromboembolic disorders and inflammatory processes, may have a similar influence on device thrombosis. In this article and throughout this issue of the Journal, we discuss biomarkers and mediators associated with arterial and venous thrombosis, atrial fibrillation, and other clinical scenarios.
|Number of pages||3|
|Journal||Journal of Thrombosis and Thrombolysis|
|State||Published - Jan 2014|
Bibliographical noteFunding Information:
Acknowledgments The authors thank Susan Quick for excellent editorial assistance. This work was supported in part by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000117 and TL1TR000115. TS was supported in part by T32HL091812 from the Heart Lung and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This material is also based on work supported in part by resources at the Lexington VA Medical Center.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine