Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

William Marciel de Souza; Marilia Farignoli Romeiro; Gilberto Sabino-Santos; Felipe Gonçalves Motta Maia; Marcilio Jorge Fumagalli; Sejal Modha; Marcio Roberto Teixeira Nunes; Pablo Ramiro Murcia; Luiz Tadeu Moraes Figueiredo

doi:10.1016/j.virol.2018.03.025

Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

William Marciel de Souza, Marilia Farignoli Romeiro, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Marcilio Jorge Fumagalli, Sejal Modha, Marcio Roberto Teixeira Nunes, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

Original language	English
Pages (from-to)	12-16
Number of pages	5
Journal	Virology
Volume	519
DOIs	https://doi.org/10.1016/j.virol.2018.03.025
State	Published - Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Funding

This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number. 13/14929-1 , and Scholarships No. 17/13981-0; 12/24150-9; 15/05778-5; 14/20851-8; 16/01414-1; 06/00572-0; 08/06411-4 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9 ).

Funders	Funder number
Medical Research Council of the United Kingdom
Medical Research Council	MC_UU_12014/9
Fundação de Amparo à Pesquisa do Estado de São Paulo	08/06411-4 11/06810-9, 16/01414-1, 13/14929-1, 17/13981-0, 11/22663-6, 16/02568-2, 12/24150-9, 15/05778-5, 06/00572-0, 14/20851-8

Keywords

Hepatitis E virus
Hepeviridae
Orthohepevirus
Rodent-borne viruses
Viral hepatitis

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.virol.2018.03.025

Cite this

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title = "Novel orthohepeviruses in wild rodents from S{\~a}o Paulo State, Brazil",

abstract = "The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from S{\~a}o Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19\%) and Calomys tener (3.66\%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.",

keywords = "Hepatitis E virus, Hepeviridae, Orthohepevirus, Rodent-borne viruses, Viral hepatitis",

author = "\{de Souza\}, \{William Marciel\} and Romeiro, \{Marilia Farignoli\} and Gilberto Sabino-Santos and Maia, \{Felipe Gon{\c c}alves Motta\} and Fumagalli, \{Marcilio Jorge\} and Sejal Modha and Nunes, \{Marcio Roberto Teixeira\} and Murcia, \{Pablo Ramiro\} and Figueiredo, \{Luiz Tadeu Moraes\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jun,

doi = "10.1016/j.virol.2018.03.025",

language = "English",

volume = "519",

pages = "12--16",

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AU - de Souza, William Marciel

AU - Romeiro, Marilia Farignoli

AU - Sabino-Santos, Gilberto

AU - Maia, Felipe Gonçalves Motta

AU - Fumagalli, Marcilio Jorge

AU - Modha, Sejal

AU - Nunes, Marcio Roberto Teixeira

AU - Murcia, Pablo Ramiro

AU - Figueiredo, Luiz Tadeu Moraes

PY - 2018/6

Y1 - 2018/6

N2 - The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

AB - The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

KW - Hepatitis E virus

KW - Hepeviridae

KW - Orthohepevirus

KW - Rodent-borne viruses

KW - Viral hepatitis

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SN - 0042-6822

VL - 519

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JO - Virology

JF - Virology

ER -

Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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